Examples of 'succinimidyl' in a sentence
Meaning of "succinimidyl"
Succinimidyl is a noun pertaining to a chemical compound commonly used in bioconjugation reactions in chemistry
Show more definitions
- A succinimide radical or functional group
How to use "succinimidyl" in a sentence
Basic
Advanced
succinimidyl
A sebacic acid ester especially a succinimidyl ester.
These are converted to succinimidyl active esters upon activation.
Succinimidyl glutaroyl chloride was similarly prepared and utilized.
Reactive groups include succinimidyl and maleimido groups.
The antibody is preferably bound to one or more fluorophores vía a succinimidyl eater moiety.
Attempts to trap the succinimidyl radical by addition to olefins were unsuccessful.
In some embodiments the linking group is succinimidyl succinate.
Other routes to succinimidyl carbonates are available and contemplated for use herein.
Higher temperatures can lead to nucleophilic ring opening of the succinimidyl group followed by a rearrangement.
Succinimidyl esters are excellent reagents since the amide products formed are very stable.
Additional amine reactive PEG linkers can be substituted for the succinimidyl moiety.
Then mPEG Succinimidyl succinate Abuchowski et al.
CFSE consists of fluorescein molecule containing two acetate moieties and a succinimidyl ester functional group.
Succinimidyl p-toluenesulfonate and chloroacetate were also prepared.
Another activated form of PEG is referred to as PEG succinimidyl propionate.
See also
The sodium sulfonate salt of succinimidyl m-maleimidobenzoate is preferred.
These succinimidyl-containing reactive groups are herein referred to as succinimidyl groups.
This biantennary PEG is synthesized using succinimidyl branched PEG.
Pyropheophorbide-a succinimidyl ester was synthesised for coupling to the scFv as follows.
The method of claim 4, wherein the fluorescent molecule is carboxyfluorescein succinimidyl ester.
Succinimidyl or benzotriazyl carbonate on the drug, or vice versa, forms a carbamate linkage.
For example, the polymer is mPEG propionaldehyde or mPEG succinimidyl propionic acid.
Succinimidyl palmitoate are then added to the solution, which is stirred overnight at room temperature.
The linking group may be a succinimide group, preferably a succinimidyl succinate group.
Alternatively, the succinimidyl ester of the above-mentioned labels may be used directly.
The process of claim 1, wherein said mPEG is activated with succinimidyl carbonate.
This succinimidyl ester, however, is so reactive that it hydrolyzes almost immediately in aqueous solution.
The process of claim 1, wherein said mPEG is activated with succinimidyl succinate.
A method of preparing a succinimidyl carbonate active ester of a branched non-antigenic polymer comprising,.
For example, lysine residues in a protein may be derivatised by reaction with a succinimidyl ester.
The succinimide derivative may be succinimidyl propionate, hydroxy succinimidyl, succinimidyl carboxymethyl, or succinimidyl carbonate.
The multi-electrophilic polyalkylene oxide may include two or more succinimidyl groups.
Carboxyfluorescein succinimidyl ester ( CFSE ) is a fluorescent cell staining dye.
Preferably, the antibodies may be bound to one or more fluorophore vía a succinimidyl ester moiety.
For example, a succinimidyl ester of carboxymethyl PEG can be formed.
In a particularly preferred embodiment of the invention, coupling groups consist of succinimidyl or maleimido groups.
The examples used succinimidyl succinate activated PEG, which is believed to react with amine groups.
In another embodiment the semi-synthetic biopolymer is bound to the succinimidyl moiety via a thioether linkage.
Y is a succinimidyl covalent link ;.
The composition of claim 8, wherein the synthetic hydrophilic polymer contains two or more succinimidyl groups.
The ease of the addition reaction suggests that this succinimidyl radical may have a? electronic configuration.
The composition according to claim 1, wherein the second component comprises a polyethylene glycol containing a succinimidyl group.
Formula 5 is a generic formula representative of succinimidyl succinate derivatives of PEG.
Succinimidyl PEGs ( as above ) comprising either linear or branched PEGs can be conjugated to rHuPH20.
Examples of such crosslinking reagents are N-maleimidobenzoyl succinimidyl ester and N-Hydroxysuccinimide.
Succinimidyl PEGs ( as above ) comprising either linear or branched PEGs have been conjugated to rHuPH20.
Additional amine-reactive PEG linkers can be substituted for the succinimidyl moiety.
Carboxyfluorescein diacetate succinimidyl ester ( CFSE ) was ordered from Invitrogen.
Non-limiting examples include Lucifer yellow and carboxyfluorescein diacetate succinimidyl ester.
Activated PEG compounds such as tresyl-PEG and succinimidyl succinate ester of PEG were mentioned.
