Examples of 'sulfatase' in a sentence
Meaning of "sulfatase"
sulfatase (noun): an enzyme that catalyzes the hydrolysis of sulfate esters. Sulfatases are important in various biological processes, including the metabolism of sulfated compounds
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- Any of several enzymes, in animals and bacteria, which catalyze the hydrolysis of organic sulfates
How to use "sulfatase" in a sentence
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sulfatase
Most estrone sulfatase inhibitors are steroidal in nature.
It is caused by a genetic insufficiency of sulfatase enzymes.
Limpet sulfatase was used as a positive control.
Enzymatic activity of another sulfatase should also be assessed.
Blank samples were obtained by incubating without estrone sulfatase.
To date thirteen sulfatase genes have been identified in humans.
Such modifications are essential for proper sulfatase function.
Placental sulfatase deficiency.
Genetic testing for a change in the iduronate sulfatase gene.
Steroid sulfatase deficiency.
A preferred binding partner is a sulfatase.
The ratio with total sulfatase can then be easily determined.
It has also been used with the steroid sulfatase gene.
Use of steroid sulfatase inhibitors for the treatment of preterm labor.
Methods can be provided for increasing sulfatase activity in a cell.
See also
Suppression of the sulfatase pathway will have a breast protective effect.
The invention embraces methods for increasing sulfatase activity in a cell.
The heterologous sulfatase motif can be present in a terminal loop of the polypeptide.
The enzyme preparation is preferably substantially free from aryl sulfatase.
An improved method for treating a sulfatase deficiency in a subject can be provided.
The sulfatase activity was strongly inhibited by phosphate but only moderately by sulfate ions.
This additional binding site results in more potent sulfatase inhibitory activity.
Other specific sulfatase motifs are readily apparent from the disclosure provided herein.
Methods for the diagnosis and therapy of sulfatase deficiencies can be provided.
The steroid sulfatase inhibitor according to the invention may be any suitable compound.
The sulfate conjugates can be transformed back into free steroids by steroid sulfatase.
The addition of sulfatase could promote the release of these growth factors from the matrices.
The invention further embraces an improved method for treating a sulfatase deficiency in a subject.
The present invention relates to sulfatase inhibitors and methods for making and using the same.
The invention also provides methods for the diagnosis and therapy of sulfatase deficiencies.
Aryl sulfatase In another embodiment the polypeptide of interest may be an arylsulfatase A.
Yet another aspect of the present invention provides a sulfatase producing microorganism Streptomyces sp.
However, such sulfatase has not been reported with osteoblasts.
Methods for using molecules in the diagnosis of Multiple Sulfatase Deficiency are provided.
In this aspect, the steroid sulfatase inhibitor is referred to as a sulfamate compound.
A preferred disorder that can be diagnosed according to the invention is Multiple Sulfatase Deficiency.
Methods for treating Multiple Sulfatase Deficiency in a subject can be provides.
A preferred disorder that can be diagnosed is Multiple Sulfatase Deficiency.
In important embodiments, the sulfatase is expressed at higher levels than normal / control cells.
The invention also embraces methods for treating Multiple Sulfatase Deficiency in a subject.
In some embodiments, the lysosomal sulfatase enzymes of the invention are substantially pure or isolated.
A rapid test for the sulfatase A.
In one embodiment, steroid sulfatase inhibitor according to the invention comprises a sulfamate group.
In particular, they inhibit steroid sulfatase activity.
Inhibitors of estrone sulfatase are therefore potential agents for the treatment of estrogen-dependent breast cancers.
In important embodiments, the endogenous sulfatase is activated.
Recombinant expression of aryl sulfatase A in a prokaryotic cell or in vertebrate cells in culture ;.
What are the symptoms of multiple sulfatase deficiency?
Figure 7 illustrates activation of sulfatases by formylglycine generating enzyme ( FGE ) and proposed sulfatase mechanism.
The cell may express an endogenous and / or an exogenous sulfatase.
