Examples of 'sulfhydryl group' in a sentence
Meaning of "sulfhydryl group"
sulfhydryl group: A sulfhydryl group is a chemical group consisting of a sulfur atom and a hydrogen atom bonded together. It is commonly found in organic compounds, particularly in amino acids and proteins. Sulfhydryl groups play a crucial role in the formation of disulfide bonds, which are important for stabilizing protein structures
How to use "sulfhydryl group" in a sentence
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sulfhydryl group
This protected sulfhydryl group was further deprotected.
The current agents do not have a sulfhydryl group.
The cysteine sulfhydryl group is nucleophilic and easily oxidized.
Cysteine has a side chain comprising a sulfhydryl group.
The resulting sulfhydryl group containing immunoglobulin is preferably purified.
Proteins can be chemically modified by standard techniques to add a sulfhydryl group.
The free sulfhydryl group can be formed by reducing a disulfide bond in an antibody.
Disulfide bonds in proteins are formed by oxidation of the sulfhydryl group of cysteine residues.
Such a free sulfhydryl group may be located in the hinge region of the antibody component.
The mucolytic action of acetylcysteine is related to the sulfhydryl group in the molecule.
This provides a sulfhydryl group on one end of the peptide for conjugation to the carrier.
The disulfide bond was reduced to produce erythropoietin containing a free sulfhydryl group.
That company was considering applying the sulfhydryl group toward cancer medication.
The derivatised tAK is reduced by reaction with mercaptoethanol to yield a reactive sulfhydryl group.
Representative cytotoxins comprising a sulfhydryl group include but are not limited to esperamicin and its derivatives.
See also
The reducing agent is added if the polypeptide contains at least one sulfhydryl group.
Annexin V contains one free sulfhydryl group and does not have any attached carbohydrate chains.
The inactivation is reversible upon dilution due to the lability of the carbamylated sulfhydryl group.
It has antioxidizing effect, sulfhydryl group may be a donor of electrons.
The eLLPs of the present invention may have a single amino group and a free sulfhydryl group.
To be effective as second attachment site, a sulfhydryl group must be available for coupling.
Cysteine Proteases Cysteine proteases have a catalytic mechanism that involves a cysteine sulfhydryl group.
In particular, a sulfur-containing compound having sulfhydryl group is particularly preferable.
Thus, a free sulfhydryl group can be critical to the biological activity of a polypeptide.
The sulfur atom can be derived from a sulfhydryl group of a Ligand.
The sulfhydryl group that a linker may be attached to may be, for example, cysteine.
The Ligand unit bonds to the Linker unit vía the sulfhydryl group.
In such cases, the sulfhydryl group is suitably protected during attachment of the chelating agent.
Generally, the link is made vía an amine or a sulfhydryl group.
The presence of free sulfhydryl group could be determined vía reaction with Ellman 's reagent.
Meanwhile, there was a significant reduction in the sulfhydryl group content.
The free sulfhydryl group was generated by deacetylation with hydroxylaminc at 4°C for two hours.
Importantly, the disulfide bond group can be reduced to a free sulfhydryl group.
Furthermore, the presence of a free sulfhydryl group in the GF domain may destabilize the protein.
For example, a targeting moiety may contain an amino group or a sulfhydryl group.
CNBr2 contains no internal lysines, a single sulfhydryl group and several carboxylic acid groups.
The conjugation group may also be a nucleophilic group, such as an amino or sulfhydryl group.
Generally, PEG is attached to a free sulfhydryl group in the muteins of EPO.
In one embodiment the alkyl groups carry thiol groups, also referred to as sulfhydryl group.
The sulfhydryl group was reacted with 5-bromoacetamido-rhodol-X in aqueous dimethylformamide.
Adding said inhibitor-linked reagent to the exposed sulfhydryl group thereon ; and.
The nucleophilic sulfhydryl group allows cysteine to conjugate to other groups, e.g., in prenylation.
The drugs are activated to become reactive with the sulfhydryl group of STxB-Cys.
All have a sulfhydryl group ( - SH ) covalently bonded to an aromatic ring.
In a further preferred embodiment, the amino acid linker comprises a sulfhydryl group or a cysteine residue.
Alternatively, a sulfhydryl group may be introduced directly to a CD38 using solid phase polypeptide techniques.
In one exemplary embodiment, the coupling reaction requires a free sulfhydryl group on the peptide.
After purification, the sulfhydryl group of N ' cysteine-tTF was protected by reaction with Ellman 's reagent.
Another example uses a maleimide-sulfhydryl bond involving a sulfhydryl group and a sulfhydryl reactive group.
Sulfhydryl group （ Cys.
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