Examples of 'syk' in a sentence
Meaning of "syk"
SYK is an abbreviation for 'See You Know'. It is often used in casual online conversations as a way to say goodbye
How to use "syk" in a sentence
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syk
Syk is also widely expressed in hematopoietic cells.
Expression and function of syk in airway epithelial cells.
Syk inhibitor fostamatinib is in trials.
Fused heteroaromatic pyrrolidinones as syk inhibitors.
Syk kinase is known to play a critical role in other signalling cascades.
Compounds of the present invention are useful as inhibitors of Syk.
Syk kinase is known to play a critical role in other signaling cascades.
Topical application of a Syk inhibitor could reduce these symptoms.
Syk deficient eosinophils also show impaired activation in response to FceRI stimulation.
The tyrosine kinase inhibitor may be active on Syk or not.
Syk kinase acts as a central initiator of all subsequent signaling leading to mediator release.
Activation and degranulation by platelets is also mediated by the Syk pathway.
Syk has emerged as a potential therapeutic target for treatment of allergic and autoimmune disorders.
The cells may optionally also express the Syk kinase substrate.
Syk also plays a key role in FCeRI mediated mast cell degranulation and eosinophil activation.
See also
Schematic representation of the metabolic pathways involving Syk tyrosine kinase in mast cells.
Thus Syk is a promiscuous messenger in various signal transduction pathways.
There remains however the need to identify further compounds which are inhibitors of Syk.
Abnormal function of Syk has also been implicated in several instances of hematopoietic malignancies.
The compound of the present invention surprisingly show excellent Syk tyrosine kinase inhibitory activity.
The Syk family is currently understood to include only Zap and Syk.
The amino acid sequences of such Syk kinases are well known and available from GENBANK.
This also has been shown for pharmacologic agents that inhibit Syk activity in mast cells.
Syk inhibitors have potential anti-inflammatory and immunomodulating activities.
The imidazopyrimidine derivatives and triazolopyrimidine derivatives of the present invention inhibit Syk tyrosine kinase activity.
Syk has been shown to be vital for phagocytosis of IgG-coated particles.
This results in the recruitment of Syk to the B cell receptor.
Phosphorylated ITAMs lead to the binding of a second set of src kinases, including syk.
Syk deficient mast cells demonstrate defective degranulation, arachidonic acid and cytokine secretion.
Such enzyme is preferably a kinase, such as the Syk kinase.
Syk is a known inhibitor of apoptosis in lymphoma B-cells.
Furthermore, an inhibitor of Syk blocked the production of these neurotoxic products.
Syk is also implicated in the signaling triggered by receptors for G-CSF.
In one embodiment, the Syk kinase is an isolated or recombinant Syk kinase.
Methods of regulating, and in particular inhibiting, Syk kinase activity are described.
In addition, Syk is suggested to be concerned in various diseases as described below.
Accordingly, the present disclosure provides compounds that function as Syk inhibitors.
In one example, the Syk kinase is an isolated or recombinant Syk kinase.
As also discussed, the active compounds are also potent inhibitors of Syk kinase.
Accordingly, Syk kinase is implicated in various allergic disorders, particularly asthma.
More specifically, these molecules do not affect the kinase enzyme activity of Syk.
The Syk protein was purified in one step using glutathione-agarose.
Alternatively, the assay may be carried out with cells that express a Syk kinase.
Accordingly, Syk kinase is implicated in various allergic disorders, in particular asthma.
Therefore, there exists a need for compounds which are able to effectly inhibit Syk kinase.
The Company 's Syk is a mediator of immune response in various types of immune cells.
However, this putative sequence is necessary but not sufficient for predicting Syk binding.
The compounds, in addition to being Syk inhibitors, possess desirable solubility and pharmacokinetic properties.
Further examples of kinase inhibitors include PI3K inhibitors, Syk inhibitors and JAK inhibitors.
All compounds tested inhibit Syk kinase phosphorylation with IC50s in the micromolar range.
