Examples of 't-butyldimethylsilyl' in a sentence
Meaning of "t-butyldimethylsilyl"
T-butyldimethylsilyl is a noun related to a chemical compound used in organic synthesis
How to use "t-butyldimethylsilyl" in a sentence
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t-butyldimethylsilyl
One of the preferred protecting groups is t-butyldimethylsilyl.
Of t-butyldimethylsilyl chloride at room temperature.
Preferred protecting groups are t-butyldimethylsilyl and acetyl.
This removal of a t-butyldimethylsilyl group is carried out by a conventional procedure.
Specific examples of silyl group are trimethylsilyl and t-butyldimethylsilyl.
A preferred silylating agent is t-butyldimethylsilyl trifluoromethanesulfonate.
A preferred serine side chain protecting group is t-butyldimethylsilyl.
Of t-butyldimethylsilyl chloride were added in portions.
In a preferred embodiment the silyl group is a t-butyldimethylsilyl group.
In a preferred embodiment, a t-butyldimethylsilyl group may be used as the protecting group.
The t-butyldiphenylsilyl protecting group can be replaced by t-butyldimethylsilyl group.
Silyl groups such as trimethylsilylethyl or t-butyldimethylsilyl may conveniently be removed using fluoride ions.
Examples of suitable trialkylsilyl groups include trimethylsilyl and t-butyldimethylsilyl.
Examples of suitable protecting agents include t-butyldimethylsilyl chloride, dihydropyrane or methoxymethyl chloride.
Suitable protecting groups include trialkylsilyl groups, such as t-butyldimethylsilyl.
See also
The t-butyldimethylsilyl protecting group was removed by treatment with 2 equivalents of tetrabutylammonium fluoride in tetrahydrofuran.
Particular examples of such silyl groups are trimethylsilyl and t-butyldimethylsilyl.
Silylation is typically achieved using t-butyldimethylsilyl chloride and imidazole using known protection technology.
An example of such a protecting group would be the t-butyldimethylsilyl ether.
Moreover, steric hindrance of t-butyldimethylsilyl group close to reactive phosphoramidite significantly diminishes coupling efficiency.
The preferred silylating agent for pyrimidine bases is t-butyldimethylsilyl triflate.
The t-butyldimethylsilyl protecting groups were removed using tetrabutylammonium fluoride as described in U. S.
Preferably, the silylating agent in the above process is t-butyldimethylsilyl chloride.
For protecting hydroxy, t-butyldimethylsilyl may be used, but with no limitations thereto.
The hydroxy protecting group may be for example the t-butyldimethylsilyl group.
The use of tetrahydropyran-2-yl and t-butyldimethylsilyl hydroxy protecting groups are generally preferred.
Examples of suitable protecting groups include the methoxymethyl and t-butyldimethylsilyl groups.
Of these, benzoyl and t-butyldimethylsilyl are preferred.
Suitable protected hydroxyl groups include trihydrocarbyl silyl ethers such as the trimethylsilyl or t-butyldimethylsilyl ether.
Especially preferred examples are trimethylsityl, t-butyldimethylsilyl and t-butyldiphenylsilyl groups.
Preferred protecting groups include methyl, carbonate, and silyl groups, such as t-butyldimethylsilyl.
Especially preferred examples are trimethylsilyl, t-butyldimethylsilyl and t-butyldiphenylsilyl groups.
Preferable examples of the substituted silyl group include trimethylsilyl, triethylsilyl, triisopropylsilyl, t-butyldiphenylsilyl and t-butyldimethylsilyl groups.
For example, trialkylsilyl ( specifically t-butyldimethylsilyl and the like ) can be mentioned.
A process according to claim 13, wherein the oxygen protecting group is t-butyldimethylsilyl.
The silylating agent includes t-butyldimethylsilyl chloride, triisopropylsilyl chloride, t-butyldiphenylsilyl chloride and so on.
Protecting groups which are removable under mild conditions such as t-butyldimethylsilyl are preferred.
A t-butyldimethylsilyl group as demonstrated by Baldwin, et al ., which is removable with fluoride ion.
Examples of suitable alkylsilyl ether radicals include trimethylsilyl, t-butyldimethylsilyl and the like.
The t-butyldimethylsilyl ( TBDMS ) group is an example of a particularly useful hydroxy-protecting group.
The olefinic alcohol optionally can be protected as a t-butyldimethylsilyl ether prior to the coupling.
When A5 is O, a t-butyldimethylsilyl group and a tetrahydropyranyl group can be used.
Isolated hydroxy groups can generally be protected as ethers including t-butyldimethylsilyl ethers, acetals and esters.
Then, 1.5 mL of t-butyldimethylsilyl trifluoromethanesulfonate were slowly added.
The preferred protecting group Y is the t-butyldimethylsilyl group.
Removal of the t-butyldimethylsilyl protecting group gives the desired compound ( 29 ).
Preferred protecting groups are 2-tetrahydropyranyl and t-butyldimethylsilyl.
After gas evolution ceases, add t-butyldimethylsilyl chloride ( 20 mmol ) and stir vigorously.
A process according to claim 13 in which the silylating agent is t-butyldimethylsilyl chloride.
Under ice-water cooling, 2.95 g of t-butyldimethylsilyl chloride was added to the mixed solution with stirring.
