Examples of 'tacrine' in a sentence
Meaning of "tacrine"
tacrine (noun): A type of chemical compound or drug that is used in medical treatments or research, particularly in relation to Alzheimer's disease
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- A synthetic drug used in Alzheimer's disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.
How to use "tacrine" in a sentence
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tacrine
Its efficacy is similar to donepezil and tacrine.
Examples include tacrine and donepezil.
Plasma was harvested and analyzed for tacrine.
Studies of the effects of tacrine on fertility have not been performed.
Preferred acetylcholinesterase inhibitors are tacrine and donepezil.
The preparation of tacrine and its derivatives is well known.
Preferred anticholinesterase inhibitors are tacrine and donepezil.
Tacrine is a very old compound known to have anticholinesterase activity.
It is a reversible inhibitor of cholinesterase that is more potent than tacrine.
Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist parasympathomimetic.
A preferred delivery device of the present invention contains tacrine.
Unsupervised increases in the dose of tacrine may also have serious consequences.
The drugs used in the study were metoprolol and tacrine.
Tacrine also causes an elevation in liver enzymes and must be taken four times a day.
One of the subgroups presents an indole moiety connected to the tacrine through a short linker.
See also
Tacrine may also diminish the effects of levodopa and increase the side effects of theophylline.
The results are in line with the fact that Tacrine is a lipophilic molecule.
Tacrine was mutagenic to bacteria in the Ames test.
Medicinal composition comprising Tacrine or Donepezil for improving brain function.
Incubations with human liver preparation D affected only partial tacrine turnover.
Some BChE inhibitors such as tacrine and huperazine A are known to inhibit acetylcholinesterase as well.
In another specific embodiment, the cholinesterase inhibitor is tacrine.
Tacrine was first synthesised by Adrien Albert at the University of Sydney.
At high doses, tacrine can damage the liver.
Tacrine is prepared according to the following reaction,.
Preferred ranges of tacrine in the carrier are,.
Figure 1 displays a proposed metabolic pathway for tacrine in man.
In a preferred embodiment the tacrine moiety has a chloro substituent at position 6.
In particular, it is claimed as an advantageous method for the preparation of tacrine.
Here Tacrine was used as the ACh'ase inhibitor.
This reference however, does not teach the synthesis of tacrine.
Tacrine was the prototypical cholinesterase inhibitor for the treatment of Alzheimer 's disease.
The presence of quinidine did not inhibit the conversion of tacrine to 1-hydroxytacrine.
The passive flux of Tacrine was relatively large, making the iontophoretic enhancement factor small.
Further, the co-administered combination provided increased latency at a submaximal dose of tacrine.
Besides, tacrine tends to cause undesirable side-effects.
However, toxic side effects also were noted when large doses of tacrine were used.
Tacrine was also described as an analeptic agent used to promote mental alertness . [ 9 ].
The most promising results were obtained using cholinesterase inhibitors, particularly physostigmine and tacrine.
These are heptyl-physostigmine and tacrine ( THA ) whose comparative actions are shown.
Anti-Demential Medicaments cholinesterase inhibitors donepezil galantamine rivastigmine tacrine.
Tacrine ( Cognex ) helps treat symptoms associated with Alzheimer 's disease or dementia.
Alzheimer 's Disease typically is treated by acetylcholine esterase inhibitors such as tacrine hydrochloride or donepezil.
In the United States and France, tacrine ( Cognex ® ) is used as a cholinesterase inhibitor.
Acetylcholinesterase inhibitors include galantamine, rivastigmine, donepezil, and tacrine.
Hepatotoxicity of thé B and C séries, bearing a tacrine fragment, was evaluated on HepG2 cells.
Alzheimer 's therapies such as donepezil, memantine, rivastigmine, galantamine and tacrine.
Tacrine has been discontinued in the US in 2013, due to concerns over safety.
Use according to claim 3 or 4, wherein the acetylcholine enhancer is donepezil or tacrine.
Preferred anticholinesterase inhibitors are tacrine ( trademark, Cognex ) and donepezil ( trademark, Aricept ).
