Examples of 'target mrna' in a sentence
Meaning of "target mrna"
Target mRNA: Refers to a specific RNA molecule that is the intended focus during gene expression or genetic research
How to use "target mrna" in a sentence
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target mrna
Expression of target mRNA in infected cells.
It is used to digest proteins that surround the target mRNA.
Blocking translation of the target mRNA or facilitating its degradation.
The siRNA preferably mediates RNAi against a target mRNA.
The target mRNA cleavage reaction guided by siRNAs is sequence specific.
The siRNA sequences can be exactly complementary to the target mRNA.
The target mRNA is destabilized by deadenylation and decapping leading to its degradation.
The seed region forms a tight duplex with the target mRNA.
Basepairing with the target mRNA sequence occurs preferentially in the cell.
The mechanism of RNAi involves the destruction of the target mRNA molecules.
The target mRNA is then loaded into the RISC complex and degraded.
Reductions in levels of a huntingtin protein are also indicative of inhibition of target mRNA expression.
Both the upstream proteins and downstream target mRNA nodes are depicted in the diagram.
This leads to a widened distribution of number of probes bound to each target mRNA.
The antisense oligonucleotide hybridizes to the complementary target mRNA and causes a block of protein tranlation.
See also
These results apply to relative rates of cleavage at a particular site in a target mRNA.
Here a RNA complementary to the target mRNA is transferred into the cell.
The siRNA of the invention preferably mediates RNAi against a target mRNA.
First, a cleavage site on the target mRNA is identified.
Signal amplification begins with the binding of the LEs to the target mRNA.
As a result, the target mRNA is degraded by the nucleases in the protein complex.
Appropriate primers are designed based upon complementarity to the target mRNA sequence.
The target mRNA species for modulation relates to intercellular adhesion molecule-1.
The siRNAs enter the RISC to silence target mRNA expression.
A probe / target mRNA duplex is a structure formed by hybridizing a probe to its target mRNA biomarker.
An antisense RNA molecule is complementary to a sequence within the target mRNA.
Figure 33 illustrates data demonstrating target mRNA silencing in hepatic tumors by the RNAi mechanism.
Such antisense RNA can inhibit the function of the target mRNA molecules.
During RNAi, siRNA induces degradation of target mRNA with consequent sequence-specific inhibition of gene expression.
The smaller RNA segments then mediate the degradation of the target mRNA.
The ribozyme recognizes and then binds a target mRNA through complementary base-pairing.
In certain embodiments, the target nucleic acid is a target mRNA.
The level of target mRNA was quantitated using the Roche LightCycler ™ real-time PCR machine.
The siRNA is then incorporated into the RISC for target mRNA degradation.
Target mRNA is then prepared using an mRNA Purification Kit ( Pharmacia ) or the like.
If complementarity is extensive, the target mRNA is cleaved.
The target mRNA sequence is typically between about 14 to about 50 nucleotides in length.
Once expressed, the nucleic acid binds to the target mRNA.
Therefore, in some embodiments, the target mRNA is a mutated form of the PCSK9 sequence.
Accordingly, each probe of a probe set has a respective target mRNA biomarker.
Values for the target mRNA were normalized versus an internal control ( e.g. beta-actin ).
In other embodiments, production of a histone protein encoded by the target mRNA is reduced.
Once expressed, the siNA molecule interacts with the target mRNA and generates an RNAi response.
The mechanism of RNAi, although not yet fully characterized, is through cleavage of a target mRNA.
The method of claim 1, wherein the target mRNA is a pathogen mRNA.
Importantly, RISC is then capable of degrading additional copies of the target mRNA.
The frozen trachea samples were analyzed for target mRNA levels by RT-PCR.
Preferably, the RNA strand is the antisense strand which binds to a target mRNA.
RNAi regulates gene expression vía a ubiquitous mechanism by degradation of target mRNA in a sequence-specific manner.
The single-stranded antisense RNA molecule is complementary to a sequence within the target mRNA.
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Examples of using Mrna
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Poliovirus mRNA is translated as one long polypeptide
One application is the rapid isolation of mRNA
That mRNA is then translated into proteins
Examples of using Target
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Your target is the fifth detainee to exit
Fund registration in the target distribution country
The target group has mainly been children
