Examples of 'targeting construct' in a sentence
Meaning of "targeting construct"
targeting construct ~ a term often used in biology or genetics to describe a molecule or system designed to specifically target a particular gene or protein
How to use "targeting construct" in a sentence
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targeting construct
The targeting construct was created as follows.
From the mouse map a targeting construct is designed.
The targeting construct is either an extrachromosomal element or a stably integrated chromosomal element.
The present invention also contemplates a targeting construct which does not include a selectable marker.
The targeting construct can contain markers for both positive and negative selection.
The nucleic acid targeting construct comprises,.
The targeting construct may be introduced directly into the host cell in a linear form.
An artificial nucleic acid targeting construct comprising,.
The targeting construct also contains a second selectable marker which is a negative selectable marker.
A pharmaceutical composition comprising the targeting construct of claim 8 and a suitable excipient.
The targeting construct also contains expression cassettes for the bacterial neo and mouse dhfr genes.
Desirably, a marker gene is used in the targeting construct to replace the deleted sequences.
The targeting construct may be introduced directly into an APP in a linear form.
An aqueous suspension comprising a gas-filled microvesicle, said microvesicle comprising a targeting construct comprising,.
The configuration of a targeting construct depends upon the specific targeting technique chosen.
See also
Preferably, the Lkt C gene is inactivated by homologous recombination using a targeting construct.
The resultant targeting construct is depicted in FIG.
Preferably, the RTX C gene is inactivated by homologous recombination using a targeting construct.
The targeting construct shown in FIG.
The method of claim 6 or 7, wherein the targeting construct is extrachromosomal.
The targeting construct according to claim 8 for use in treatment of cancer.
However, the exon 1 targeting construct of Li et al.
The targeting construct of claim 1, wherein the heterologous promoter is an inducible promoter.
The single-copy replacement of the targeting construct was confirmed using a 5 ' fragment of B geo.
The targeting construct of claim 1, wherein the heterologous promoter is a constitutive promoter.
A large plasmid preparation of the pAMGENK03-OPGL-KI targeting construct was prepared using Qiagen plasmid Mega kit.
The targeting construct was linearized with NotI and transfected into CJ7 ES cells by electroporation.
A higher targeting efficiency with the BALB / c targeting construct than with the non-isogenic 129 targeting construct ( Table 1 ).
The targeting construct according to claim 14, wherein said O-glycan moiety comprises a sialyl Lewis x structure.
Preferably, said targeting construct is a recombinant fusión protein.
The targeting construct was electroporated into ES-D3 cells.
Generally, a replacement-type targeting construct is employed for homologous gene replacement.
The targeting construct contained the mcherry ( M ) gene.
Alternatively, the targeting construct may be introduced vÃa a suicide or non-replicating vector.
The targeting construct according to claims 7 to 12 wherein XA comprises two Cysteine residues.
Parts 3 and 4 of the targeting construct are most critical with respect to the invention.
The targeting construct according to claim 7, wherein Y is Lysine.
Preferably, the targeting construct contains markers for both positive and negative selection.
The targeting construct according to any one of claims 10-11, for use in treatment of cancer.
For example, the targeting construct can encode a desired VHDHJH polypeptide.
The targeting construct of claim 1, wherein the targeting moiety is directed to Her-2.
For example, the targeting construct may include a segment of the RTX C gene which contains a deletion.
The targeting construct can be employed, for example, in embryonal stem cell ( ES ).
For example, the targeting construct can be made in the cre-lox vector.
The targeting construct according to claim 7, wherein M is 0.
Additionally, the targeting construct can include a selectable marker ( Fig . 3D ).
FIG . 11 ( d ) shows a targeting construct for replacing mTPO gene with hTPO gene.
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Examples of using Targeting
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It seems someone is targeting rich guys in seattle
The targeting of humanitarian personnel in a conflict is unacceptable
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