Examples of 'tcrs' in a sentence
Meaning of "tcrs"
TCRS (noun): Acronym for Total Current Received Signal, often used in the context of telecommunication or electrical engineering
Show more definitions
- plural of TCR
How to use "tcrs" in a sentence
Basic
Advanced
tcrs
Methods to make such TCRs are known in the art.
Assessment of biotinylation of the biotinylated TCRs.
Methods to make such TCRs is known in the art.
Both of these receptor types interact with TCRs.
Such polypeptide chains of TCRs are known in the art.
The latter was properly recognized by some of the TCRs only.
Each of the plurality of soluble TCRs is preferably identical.
This is for example seen for antibodies and TcRs.
Such polypeptides chains of TCRs are known in the art.
Only TCRs with a high affinity will induce an immune response.
Two designs for the fusión TCRs were tested.
In naturally occurring TcRs there are four CDRs in each variable region.
The complexities involved in constructing a library of TCRs are enormous.
This strategy of producing TCRs is generally applicable to all TCRs.
Included are functional variants of the inventive TCRs described herein.
See also
The inventive human TCRs further comprise a human constant region.
Previous attempts at making and using recombinant TCRs have been made.
Diversity is also achieved in TCRs by alternative joining of gene segments.
Marker TCRs associated with a given disease are identified using known techniques.
There have been reports of specific TCRs which recognize particular antigens.
It is particularly preferred if these mutations are introduced into defined domain of the TCRs.
A plurality of soluble TCRs of the present invention may be provided in a multivalent complex.
A number of constructs have been devised to date for the production of recombinant TCRs.
Phenotypically silent variants of such TCRs also form part of this invention.
Single chain TCRs may also be used as soluble constructs in a way similar to antibodies.
The invention also includes high affinity TCRs identifiable by these methods.
Peptides derived from altered or mutated proteins in tumors can be recognized by specific TCRs.
These elements can then be replaced by alternative TCRs using these restriction sites.
For TCRs and antibodies according to the invention the presentation is the determining factor.
An additional display methodology suitable for the creation of TCRs libraries is mammalian cell display.
This demonstrates that TCRs with high specificity for antigen can be isolated from the library.
Common structural features among the variable regions of both TCRs and antibodies are well known.
This demonstrates TCRs isolated from the library have a useful affinity for the corresponding antigen.
Such analysis can further pinpoint the critical antibodies or TCRs mediating an effective immune response.
TCRs were purified and refolded from inclusion bodies.
A TCR complex of the invention may have the TCRs linked by a polyalkylene glycol chain.
TcRs do not generally show binding to antigen alone.
T cells may recognize these complexes using their T cell receptors TCRs.
Native TCRs exist in heterodimeric aB or Yδ forms.
The DN subpopulation of T cells is distinctive in regard to the TCRs that they display.
TCRs of the present invention are soluble.
Embodiments of the invention include TCRs which are mutated relative to the parental AFP TCR.
TCRs also do not undergo the same extent of affinity maturation as antibodies.
In this respect, immunocompetence is reflected in the diversity of TCRs.
The TCRs of T cell clones specific for the peptides of the invention are cloned.
In certain embodiments, all of the TCRs are the same.
The TCRs of CTL clones specific for the peptides of the invention are cloned.
These candidates can be fully human antibodies and / or TCRs.
TCRs can not recognise antigens directly.
As stated above, the TCRs of the present invention are soluble.
