Examples of 'tert-butoxycarbonyl' in a sentence
Meaning of "tert-butoxycarbonyl"
tert-butoxycarbonyl (t-butoxycarbonyl) is a chemical compound commonly used in organic synthesis for protecting amino groups in molecules
How to use "tert-butoxycarbonyl" in a sentence
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tert-butoxycarbonyl
Boc represents a tert-butoxycarbonyl group.
Preferred examples thereof may include a methoxycarbonyl group and a tert-butoxycarbonyl group.
Lower alkoxycarbonyl is especially tert-butoxycarbonyl or more especially methoxycarbonyl.
The first step is the step for protection of hydrazine with tert-butoxycarbonyl group.
In Scheme II, tert-butoxycarbonyl can be other suitable nitrogen protecting group such as benzyloxycarbonyl.
The group preferred is tert-butoxycarbonyl.
PG is preferably tert-butoxycarbonyl or benzyloxycarbonyl, L is preferably a pentafluorophenoxy group.
Acidic conditions for the removal of a tert-butoxycarbonyl group.
Especially, tert-butoxycarbonyl group is convenient.
Particularly preferred is tert-butoxycarbonyl.
Preferaby tert-butoxycarbonyl is used.
An amino group one or two times substituted with tert-butoxycarbonyl or fluorobenzyl ;.
Thus e.g. tert-butoxycarbonyl may be removed by treatment with a suitable acid.
Particular amino-protecting groups are tert-butoxycarbonyl group and dimethoxytrityl.
Selected examples of specific substituents on Rc include acetyl and tert-butoxycarbonyl.
See also
If C is a nitrogen protecting group such as tert-butoxycarbonyl the activated form may be an anhydride.
In that case the protecting group for the amino function is preferably the tert-butoxycarbonyl group.
Boc means a tert-butoxycarbonyl group.
Particularly suitable amino protecting groups include alkoxycarbonyl groups such as tert-butoxycarbonyl and benzyloxycarbonyl.
Methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl can be removed by using an acid e . g.
Preferred examples include a benzyloxycarbonyl group, a substituted benzyloxycarbonyl group, a tert-butoxycarbonyl group and the like.
Carbamates, for example, the tert-butoxycarbonyl moiety are suitable.
Examples include methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, and tert-butoxycarbonyl.
P 3 preferably is a tert-butoxycarbonyl group.
More preferred are benzyloxycarbonyl, methoxycarbonyl, ethoxycarbonyl and tert-butoxycarbonyl.
Is primarily tert-butoxycarbonyl.
In another embodiment, the amino protecting group is tert-butoxycarbonyl.
The deprotection of tert-butoxycarbonyl groups is well-known in the art.
Suitable amino or nitrogen protecting groups include benzyl, tert-butoxycarbonyl and toluensulfonyl.
Thus, for example, tert-butoxycarbonyl groups may be removed by hydrolysis under acidic conditions.
The more preferable specific examples are tert-butoxycarbonyl and benzyloxycarbonyl.
Representative examples of alkoxycarbonyl are methoxycarbonyl, ethoxycarbonyl, and tert-butoxycarbonyl.
Suitable protecting groups include acyl groups such as tert-butoxycarbonyl or benzyloxycarbonyl and the like.
Representative examples of alkoxycarbonyl include methoxycarbonyl, ethoxycarbonyl, and tert-butoxycarbonyl.
Particularly preferred is a 2-propenyloxycarbonyl group, a tert-butoxycarbonyl group or a p-nitrobenzyloxycarbonyl group.
Nonlimiting examples include methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, isopropoxycarbonyl and tert-butoxycarbonyl.
The preferred P group is the tert-butoxycarbonyl group.
Representative examples of alkoxycarbonyl include, but are not limited to, methoxycarbonyl ; ethoxycarbonyl, and tert-butoxycarbonyl.
Examples of the protective group P1 include a tert-butoxycarbonyl group and the like.
Representative examples of allcoxycarbonyl include, but are not limited to, methoxycarbonyl, ethoxycarbonyl, and tert-butoxycarbonyl.
Especially preferable amino-protecting groups are the tert-butoxycarbonyl ( t-BOC ) and benzyloxycarbonyl groups.
Examples of " lower alkyloxycarbonyl " include methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl and tert-butoxycarbonyl.
According to the present invention, the advantages of tert-butoxycarbonyl group are as follows.
Examples thereof include a tert-butoxycarbonyl group, an acetyl group, a formyl group, a trifluoroacetyl group and a phthaloyl group.
With regard to a protective group for amino group, tert-butoxycarbonyl group is preferred.
The tert-butoxycarbonyl group is illustrated in SCHEME 5 above.
A represents NHBoc with Boc being a tert-butoxycarbonyl group.
In the present instance, tert-butoxycarbonyl ( Boc ) group has been found to be a satisfactory protective group.
A preferred protecting group PG is the tert-butoxycarbonyl group.
The tert-butoxycarbonyl moiety is, therefore, one of the preferred N-protecting groups for the phenylalanine.
