Examples of 'thrombospondin' in a sentence
Meaning of "thrombospondin"
Thrombospondin is a glycoprotein that is involved in cell-to-cell and cell-to-matrix interactions in various tissues. It plays a role in cell adhesion, migration, and proliferation
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- Any of a family of glycoproteins secreted into the extracellular matrix by various types of cell, which play a role in cellular adhesion in processes including thrombocyte aggregation, tumor metastasis, and angiogenesis.
How to use "thrombospondin" in a sentence
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thrombospondin
Thrombospondin and some other components are antiviral.
The pharmaceutical compositions comprise thrombospondin as the active ingredient.
The thrombospondin gene family.
Certain matrix glycoproteins such as thrombospondin are also useful in this regard.
But no one knew the exact mechanism by which the formation of synapses induced thrombospondin.
It is believed that thrombospondin acts in metastasis through its adhesive properties.
Schematic drawing of thrombospondin.
The mechanisms by which the thrombospondin potentiation occurs are not presently well understood.
Examples of adhesive glycoproteins include fibronectin ; tenascins ; and thrombospondin.
Five further selection cycles with the thrombospondin peptide were carried out in this way.
TSP thrombospondin The following examples are intended to illustrate the invention.
It also inhibits the agglutination of fixed, activated platelets by thrombospondin.
Use of thrombospondin fragments as immunogens to generate fragment-specific antibodies,.
Measuring in a sample the individual 's plasma level of a thrombospondin fragment or fragments ;.
Thus, it should bind to thrombospondin but not to major circulating fragments.
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This region is recovered as a 50kDa fragment after chymotryptic digestion of thrombospondin.
Here, the antigen would be based on a thrombospondin fragment present in a cancer patient.
This antibody inhibits the hemagglutination of trypsinized, glutaraldehyde-fixed human erythrocytes by purified thrombospondin.
The heparin-binding domain of thrombospondin is expected to be absent from the circulating fragments.
Anti-TSP refers to the binding of a MoAb against thrombospondin.
Fibronectin, vitronectin and thrombospondin are proteins which have also been demonstrated to bind to GPIIb-IIIa.
Members of the ADAMTS ( a disintegrin and metalloproteinase with thrombospondin motifs ) subfamily were also examined.
ADAMTS13 has eight thrombospondin domains and no hydrophobic transmembrane domain.
In some embodiments such agents do not interfere with the interaction between CD47 and thrombospondin.
Thrombospondin is represented by the amino acid sequence described in Lawler et al ( supra ).
The sequence of the human thrombospondin ( TSP ) is available from GenBank accession no.
Several inhibitors of angiogenesis have also been reported, including thrombospondin D.
Five thrombospondin type I repeats are indicated - in large case letters.
The negative regulators so far identified include thrombospondin Good et al . Proc.
Fibronectin, Thrombospondin and von Willibrands Factor are also crosslinked into this region.
Moreover, HCV core protein activated the latent form of TGF-Β through increased thrombospondin expression.
The thrombospondin-1 protein is a member of the thrombospondin family.
While interferon-alpha, interferon-beta and thrombospondin are examples of angiogenesis suppressors.
Heparin efficiently inhibits the binding of Ab-9 to thrombospondin.
Ab-6 blocks the binding of thrombospondin to sulfatides at low concentrations.
Thrombospondin analogs of the invention were synthesized as described in Examples 1-3.
ADAMTS13 in fact has eight thrombospondin domains.
Included among ECM proteins are collagen, proteoglycans, fibronectin, laminin, tenascin, entactin and thrombospondin.
The thrombospondin family includes five proteins, TSP1 to TSPS, and is divided into two subgroups.
ADAMTS5 is a member of the ADAMTS ( a disintegrin and metalloproteinase with thrombospondin motifs ) protein family.
In this assay, thrombospondin purified by the method of Tuszynski et al ., J.
Collagen, proteoglycans, fibronectin, laminin, tenascin, entactin and thrombospondin are among the ECM proteins.
Thrombospondin type I ( TSP1 ) repeats are shown as numbered circles.
Heparin or EDTA may marginally affect binding of Ab-3 to thrombospondin.
Adamts ( a disintegrin and metaloproteinase with thrombospondin motifs ) are dependent on zn2+/ca2 + enzymes.
CD36 is expressed in endothelial cells, platelets, and monocytes, and binds to thrombospondin 1.
The term “ TSRC1 ” means human thrombospondin repeat containing 1.
A disintegrin-like and metalloprotease ( reprolysin type ) with thrombospondin type 1 motif, 9.
Proteins such as thrombospondin ( Tsp-1 ), angiostatin, and endostatin function as negative regulators of angiogenesis.
The negative regulators so far identified include thrombospondin Good et al . Proc . Nati . Acad.
