Examples of 'tolterodine' in a sentence
Meaning of "tolterodine"
Definition: A medication used to treat overactive bladder. It helps to control the muscles in the bladder
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- An antimuscarinic drug used to treat urinary incontinence.
How to use "tolterodine" in a sentence
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tolterodine
Newer drugs include tolterodine and tamsulosin.
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In plasma concentrations of tolterodine have been observed.
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Patients take tolterodine twice a day.
A process for the preparation of tolterodine.
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A number of processes for the preparation of tolterodine are known.
When tolterodine is used to treat urinary incontinence it is administered perorally as a tablet.
Several salts of tolterodine were prepared.
The tolterodine base and placebo patches were applied to the rabbits.
Active metabolites of tolterodine are hydroxytolterodines.
The coating suspension is sprayed on the microgranules mounted with tolterodine.
A process for the preparation of tolterodine and intermediates thereof.
Stereoisomer of tolterodine is also preferred as anticholinergic drug in the present invention.
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This effect is primarily achieved through the systemic effect of tolterodine.
Tolterodine has generally been associated with less dry mouth than oxybutynin.
The only compounds prescribed in significant quantities are tolterodine and oxybutynin.
Tolterodine can be bound in the cavities of cyclodextrines to form so called inclusion complexes.
Particularly preferred is tolterodine.
Acid salt of tolterodine having effective stability for transdermal drug delivery system.
Anyhow none of the above substances have any similarities with tolterodine.
Stock solutions of pilocarpine HCl and tolterodine tartrate were prepared as working standards.
Oxobutynin has a chemical structure being totally different from the one of tolterodine.
Various carriers and vehicles for tolterodine may be used in the transdermal administration.
The compounds of formula VII and IX are intermediates in the synthesis of tolterodine.
Preferred tolterodine salt is tolterodine tartrate which is an acid addition salt with tartaric acid.
The present invention relates to a process for the preparation of tolterodine and intermediates thereof.
The amount of tolterodine base in the samples was determined by HPLC.
Specifically, the compounds are certain salts of tolterodine or hydroxytolterodine.
Background Tolterodine is an effective and safe compound for treatment of overactive bladder.
Thus, seven different salts of tolterodine have been isolated.
Tolterodine Tartrate was mixed with Kollidon SR to form a homogenous mixture.
Reservoir formulation study The tolterodine base was dissolved in ethanol and propylene glycol.
There was no difference between transdermal oxybutynin and extended-release oral tolterodine.
Antispasmodic Tolterodine No interaction study performed.
Rivastigmine might interfere with the activity of anticholinergic medicinal products e . g oxybutynin, tolterodine.
In some embodiments, the tolterodine is tolterodine tartrate.
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In summary, seven different salts of tolterodine have been crystallized.
Clearly, tolterodine is rapidly absorbed into the circulation.
Because of anticholinergic side effects, the tolterodine was introduced with partial success.
For tolterodine base in solution 2 also human full thickness skin was used.
Further, its transdermal absorption rate is much lower than that of tolterodine free base form.
The 5-hydroxymethyl metabolite of tolterodine mentioned above contributes significantly to the therapeutic effect of tolterodine.
Table 3 is an overview showing different transdermal formulations with tolterodine base according to Example 9.
In one embodiment, tolterodine is used as the muscarinic Inhibitor in the medicament.
Examples Example 1 In vitro skin permeation studies from solutions of tolterodine base.
The amount of tolterodine ( calculated as base ) in the samples was determined by HPLC.
The present invention encompasses transdermal administration of tolterodine as R-isomer . Prior Art.
