Examples of 'tolvaptan' in a sentence
Meaning of "tolvaptan"
'Tolvaptan' is an adjective pertaining to a specific medication that is used to treat hyponatremia, or low levels of sodium in the blood
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- A certain vaptan drug used to treat hyponatremia and potentially polycystic kidney disease.
How to use "tolvaptan" in a sentence
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tolvaptan
Clearance of tolvaptan is not significantly affected by age.
Jinarc contains the active substance tolvaptan.
Effect of tolvaptan on the pharmacokinetics of other products.
There is no specific antidote for tolvaptan intoxication.
Tolvaptan is not recommended in the paediatric age group.
It is unknown whether tolvaptan is excreted in human milk.
Samsca contains the active substance tolvaptan.
Tolvaptan is extensively metabolised by the liver.
Exemplary vasopressin receptor antagonists include tolvaptan.
A combination of tolvaptan with octreotide is even more preferable.
The elevations gradually improved after discontinuation of tolvaptan.
Increasing age has no effect on tolvaptan plasma concentrations.
Tolvaptan has not been studied in patients with severe renal failure.
Studies in rats have shown excretion of tolvaptan in milk.
Patients taking tolvaptan should avoid ingesting grapefruit juice.
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The active substance is tolvaptan.
Tolvaptan is used in the treatment of low levels of sodium in the blood.
In plasma concentrations of tolvaptan have been observed.
Patients have to be maintained on the highest tolerable tolvaptan dose.
Tolvaptan may be a prodrug.
The combination is preferably a combination of tolvaptan with a somatostatin derivative.
Decreased uric acid clearance by the kidney is a known effect of tolvaptan.
Tolvaptan has not been studied in a setting of urgent need to raise serum sodium acutely.
There are no adequate data from the use of tolvaptan in pregnant women.
Tolvaptan metabolites do not appear to have relevant pharmacological activity at clinical concentrations in humans.
This type of reaction occurred after the first administration of tolvaptan.
Vasopressin antagonists Tolvaptan showed to have no benefit.
An example of a prodrug is a compound produced by phosphorylation of the hydroxy group of tolvaptan.
Tolvaptan has not been extensively studied in ADPKD in combination with diuretics.
This condition must be excluded prior and during treatment with tolvaptan.
Adverse reactions associated with tolvaptan obtained from ADPKD clinical studies are tabulated below.
This condition should be excluded prior and during treatment with tolvaptan.
Effect of tolvaptan on glomerular filtration rate GFR.
Women of childbearing potential have to use effective contraception during tolvaptan treatment.
Tolvaptan is only a minor component in plasma 3.
Women of childbearing potential should use adequate contraceptive measures during tolvaptan use.
In the present invention, tolvaptan is preferable.
Other examples of prodrugs include a compound obtained by acylating the hydroxy group of tolvaptan.
In contrast, there was no effect of tolvaptan on either progression of hypertension or albuminuria.
Further reductions have to be considered if patients can not tolerate the reduced tolvaptan doses.
Tolvaptan according to claim 1 for use in a method of reducing cardiotoxicity.
Patients receiving digoxin should therefore be evaluated for excessive digoxin effects when treated with tolvaptan.
Tolvaptan according to claim 1 for use in a method of improving survival.
Therefore, diabetic patients treated with tolvaptan must be managed cautiously.
Tolvaptan is also effective in preventing and / or treating polycystic kidney diseases.
Therefore, diabetic patients treated with tolvaptan should be managed cautiously.
Tolvaptan was also in fast-track clinical trials for polycystic kidney disease.
Blood samples were periodically collected, and the tolvaptan concentration in plasma was measured.
Fig . 2 shows tolvaptan plasma concentration after administration under fasting conditions.
When crystals have two or more polymorphisms, tolvaptan includes all of the polymorphisms.
