Examples of 'tosylate salt' in a sentence
Meaning of "tosylate salt"
tosylate salt: A chemical term referring to a compound containing the tosylate group, often used in organic chemistry reactions and synthesis
How to use "tosylate salt" in a sentence
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tosylate salt
The tosylate salt precipitated as a white solid.
The preferred salt is the tosylate salt.
Tosylate salt of a therapeutic compound and pharmaceutical compositions thereof.
The stability study of the crystalline tosylate salt was continued.
The tosylate salt may be prepared under a variety of different conditions.
The suspension was seeded with crystalline tosylate salt and allowed to stir overnight.
The tosylate salt of the desired product was collected and dried in vacuo.
The form 1 polymorph tosylate salt is a seed crystal.
The tosylate salt obtained may be used directly in the next step.
In preferred embodiments, SAMe is a SAMe disulfate tosylate salt.
The tosylate salt of a compound of formula 1.
In one aspect, the present invention provides a tosylate salt of perindopril.
In one embodiment, the tosylate salt form is substantially crystalline.
Form 1 can also be obtained from recrystallization of the amorphous tosylate salt slurried in isopropanol.
In one embodiment, the tosylate salt form is substantially amorphous.
See also
A compound according to Claim 1 which is a tosylate salt.
In one embodiment, the tosylate salt form is partially amorphous.
Gravimetric vapor sorption was performed on Compound 1 or its tosylate salt.
As disclosed herein, the tosylate salt form may be substantially amorphous.
For example, the invention relates to a polymorph of a tosylate salt of Compound 1.
In addition, the tosylate salt is better suited for pharmaceutical formulation.
A single crystal X-Ray of the tosylate salt II was obtained.
Alternatively, the tosylate salt of the secondary amine may be isolated from imine reduction.
The polymorphs can be polymorphs of the tosylate salt of Compound 1.
The crystalline tosylate salt seed may be prepared by the following method,.
In one embodiment, the present invention provides a polymorph of a tosylate salt of Compound 1.
As disclosed herein, the tosylate salt form may be partially amorphous.
The salt as recited in claim 1, wherein the salt is the tosylate salt.
As disclosed herein, the tosylate salt form may be substantially crystalline.
In some such embodiments, for example, the salt comprises a trifluoroacetate, mesylate, or tosylate salt.
The tosylate salt of Compound 1 was isolated as an orange powder.
Three polymorphic forms of the tosylate salt of Compound 1 were observed.
The tosylate salt of Compound 1 can be more stable than the free base of Compound 1.
In certain embodiments, the tosylate salt of compound 1 is compound 8.
The tosylate salt according to claim 1 or 2, wherein the salt is anhydrous.
Upon removal of solvent, the tosylate salt was obtained as an off-white solid.
The tosylate salt was dissolved in water and adjusted to a pH of 12 with 1N sodium hydroxide.
For example, the form 1 polymorph tosylate salt is a seed crystal.
The crystalline tosylate salt was determined to have the solubilities summarized in Table 6 below.
A crystalline form of a tosylate salt of Compound 1,.
The tosylate salt was of fair crystallinity ( PXRD not shown ).
The polymorph of claim 2 obtained by crystallizing a tosylate salt of Compound 1, from isopropanol.
A polymorph of a tosylate salt of Compound 1, obtained according to the method of claim 4.
Further described herein is a method of preparing Form A of tosylate salt of Compound ( 1 ).
Polymorphic forms of the tosylate salt of Compound 1 can be formed by a solution method.
Variable temperature XRPD was performed on form 2 and form 3 tosylate salt of Compound 1.
The tosylate salt is then treated with trifluoromethanesulfonic anhydride and n-methyl morpholine to provide ( DD ).
A method of preparing a stable crystalline tosylate salt of Compound 1, wherein the method comprises,.
Example 10, Photostability Study A photostability study was conducted on the tosylate salt of Compound 1.
In certain embodiments, the tosylate salt of compound 1 is Form B of compound 8.
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The preferred salt is the tosylate salt
The tosylate salt precipitated as a white solid
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