Examples of 'trinucleotide' in a sentence
Meaning of "trinucleotide"
trinucleotide (noun): Trinucleotide refers to a sequence of three nucleotides in a DNA or RNA molecule. These sequences play a crucial role in genetic coding and can affect protein synthesis and gene expression. Trinucleotide repeats are implicated in certain genetic disorders and diseases, including neurological conditions like Huntington's disease
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- a codon containing three nucleotides
How to use "trinucleotide" in a sentence
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trinucleotide
Trinucleotide repeat disorders are preferred conditions to be treated.
This is readily achieved during trinucleotide synthesis.
The precipitated trinucleotide is purified by chromatography on silica gel.
All nontranscribed spacers contained a variable number of trinucleotide tandem repeats.
A discussion of expanding trinucleotide repeats as cause of neurological diseases.
A number of human diseases are caused by the expansion of a trinucleotide pair repeat.
The trinucleotide is shown by three filled circles surrounded by a rectangle.
Monomeric building blocks used prior to trinucleotide coupling are filled circles.
Expansion of trinucleotide repeats is now recognized as a major cause of neurological disease.
Also called trinucleotide.
Trinucleotide repeats are classified as insertion mutations and sometimes as a separate class of mutations.
Those added after the trinucleotide are indicated by hatched circles.
Southern blotting is still useful in the diagnosis of disorders caused by trinucleotide repeats.
They comprise tandem or trinucleotide repeats that normally are inherited in a stable fashion.
The normal synthesis programme is used until it is necessary to couple the trinucleotide.
See also
Many genes normally contain a trinucleotide repeat which is present several times.
Each trinucleotide repeating sequence is transcribed into a repeating series of the same amino acid.
The disorder is related to the expansion of a trinucleotide repeat within this gene.
A trinucleotide specifying a leucine codon can be custom synthesized using standard solution phase chemistry.
Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene.
Trinucleotide expansions are a subset of unstable microsatellite repeats that occur throughout all genomic sequences.
Continuing DNA synthesis by coupling of either monomers or additional trinucleotide sequences.
The two perfect dinucleotide and one trinucleotide microsatellite DNA loci were the most informative.
The Cas protein derived from Streptococcus pyogens may recognizes NGG trinucleotide.
DNA replication and DNA repair in trinucleotide repeat stability.
The start nucleotide can be a mononucleotide, a dinucleotide or a trinucleotide.
Run a DNA test for CAG trinucleotide repeats in chromosome four.
In certain embodiments, the neurodegenerative disease is a trinucleotide repeat disease.
An example of a trinucleotide repeat disease is Fragile-X syndrome.
In reference to this common mechanism, these disorders are called trinucleotide repeat diseases.
Microsatellites are di - or trinucleotide repeats found throughout the genome.
The trinucleotide can be added at different points in the sequence of the wild-type gene.
At present there are 14 documented trinucleotide repeat disorders that affect humans.
Particularly suitable target sites comprise repetitive nucleic acid sequences ; especially trinucleotide repeat sequences.
All of these trinucleotide repeat expansion disorders are well-characterized.
A variety of SSRs were present, although perfect trinucleotide repeat arrays were the most common.
A trinucleotide repetition of up to 35 units of CAG sequences is considered normal.
For example, a tuplet can be a dinucleotide, a trinucleotide or can also be four or more nucleotides.
The trinucleotide and monomeric building blocks are as defined for Figure 1.
In a further preferred embodiment, the trinucleotide repeat is CUG.
Tandem repeats of trinucleotides are abundant in Dictyostelium, which in humans cause Trinucleotide repeat disorders.
This sequence, which is written as CAG, is called a triplet or trinucleotide repeat.
Based on the above four trinucleotide mixtures, another four mixtures were generated.
A method as in claim 1 wherein said DNA polymorphism is a trinucleotide repeat expansion.
This phenomenon occurs in a number of trinucleotide repeat diseases, one example being Huntington 's disease.
The FMR1 gene is located on the X chromosome and contains a repeated CGG trinucleotide.
Data in Table 1 show the effects of FpFpF trinucleotide in comparison with dFdC.
In another procedure, trinucleotide phosphoramidates have been synthesized by Kayushin Kayushin AL et al.
Objective, To demonstrate a higher stability of the FpFpF trinucleotide in human serum compared to dFdC.
The trinucleotide representing codon 19 is underlined.
