Examples of 'trna synthetase' in a sentence
Meaning of "trna synthetase"
tRNA synthetase - This term refers to a group of enzymes responsible for catalyzing the specific attachment of transfer RNA (tRNA) to their corresponding amino acids during protein synthesis
How to use "trna synthetase" in a sentence
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trna synthetase
Preferably a tRNA synthetase fragment in a container is purified.
The polypeptide is part of a tRNA synthetase.
Optionally a tRNA synthetase fragment is isolated.
The polypeptide is preferably part of a tryptophan tRNA synthetase.
The tRNA synthetase may be an aminoacyl tRNA synthetase.
Any of the monomers can comprise a tRNA synthetase fragment.
A tRNA synthetase fragment is preferably isolated.
Described herein are compounds that exhibit tRNA synthetase inhibition.
The tRNA synthetase may be a mutant tRNA synthesis.
In some cases a polynucleotide sequence herein encodes a modified tRNA synthetase fragment.
A tRNA synthetase fragment is preferably a tryptophanyl tRNA synthetase fragment.
Other ratios of a first and a second tRNA synthetase fragments may also be utilized.
Such tRNA synthetase may under appropriate conditions form dimers.
The editing domain is encoded by a portion of the aminoacyl tRNA synthetase involved in proofreading.
A specific tRNA synthetase is responsible for recognizing and charging a particular amino acid.
See also
A polynucleotide sequence may encode a first and a second tRNA synthetase fragments in tandem.
The tryptophanyl tRNA synthetase fragments may be mammalian or human and have angiostatic activity.
The acceptor stem of the tRNA is a key determinant for tRNA synthetase recognition.
Examples of tRNA synthetase fragments include tryptophanyl tRNA synthetase fragments and tyrosyl tRNA synthetase fragments.
In some cases the expression vector also encodes a second tRNA synthetase fragment.
Moreover, a tRNA synthetase fragment is preferably purified.
In some cases a polynucleotide of the invention encodes two or more modified tRNA synthetase fragments.
Preferably such tRNA synthetase fragment is anti-angiogenic.
Such linker may be situated between the first and the second tRNA synthetase fragments.
Optionally, a tRNA synthetase fragment is purified.
A nucleotide sequence encoding a linker can be inserted between two nucleotide sequences tRNA synthetase fragments.
Optionally, a tRNA synthetase fragment has angiostatic activity.
Optionally the modifying step involves generating an expression vector encoding two tRNA synthetase fragments.
In another instance, the tRNA synthetase is leucyl tRNA synthetase.
PheS PheS is the alpha subunit of the two subunit protein phenylalanine tRNA synthetase.
Preferably, such tRNA synthetase fragments are tryptophanyl tRNA synthetase fragments.
The business methods herein also contemplate commercializing fragments of a tRNA synthetase that modulate angiogenesis.
In some embodiments, a tRNA synthetase fragment herein has a hydrophobic cleft.
In another embodiment, the metabolic enzyme is a tRNA synthetase.
Preferably such compositions and / or tRNA synthetase fragments are substantially pure.
In another aspect, the metabolic enzyme is a tRNA synthetase.
In an instance, the tRNA synthetase is derived from leucyl tRNA synthetase.
In an instance, the enzyme is an editing domain of a tRNA synthetase.
In another exemplary embodiment, the tRNA synthetase is leucyl tRNA synthetase.
In an exemplary embodiment, the enzyme is an editing domain of a tRNA synthetase.
A tRNA synthetase of the present invention is preferably mammalian, or more preferably human.
Table 6 below summarizes various vector constructs of tRNA synthetase fragments.
Optionally, both of such tRNA synthetase fragments are tryptophanyl tRNA synthetase fragments.
Figure 16 illustrates exemplary mutations made in a yeast phenylalanine tRNA synthetase.
Preferably, the tRNA synthetase fragments herein are tryptophanyl-tRNA synthetase fragments.
Among the translation-directed commercial antibiotics one is targeted to a tRNA synthetase.
Optionally, at least one of such tRNA synthetase fragments is a tryptophanyl tRNA synthetase fragment.
Preferably, such modification occurs in the dimerization domain of the tRNA synthetase fragment.
The tryptophanyl tRNA synthetase fragments herein are preferably mammalian, or more preferably human.
This aminoacyl-tRNA is produced in an ATP-dependent reaction carried out by an aminoacyl tRNA synthetase.
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