Examples of 'up-regulation' in a sentence
Meaning of "up-regulation"
Upregulation usually refers to the process in biology where cells increase the number of receptors in response to a decrease in the availability of a specific molecule. It can also relate to the enhancement of a biological response or pathway
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- Alternative spelling of upregulation
How to use "up-regulation" in a sentence
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up-regulation
Up-regulation of gene expression in vitro and in vivo.
Inhibition of up-regulation of pain genes.
Up-regulation of a gene that reduces phytate content.
This provides a potential mechanism for the observed up-regulation.
There is an up-regulation of the steps in energy metabolism.
These mechanisms were correlated with the up-regulation of stress-responsive genes.
Receptor up-regulation occurs in response to low hormone concentrations.
T cell activation is accompanied by a strong up-regulation of PrP, though it is not requisite.
Alternatively, up-regulation of an enzyme may be detected by an immunological assay.
They conclude that cerebral ischemia leads to an up-regulation of endostatin in the brain.
Comparing the up-regulation of the polypeptide to matched normal controls.
Peripheral nociceptors can be stimulated with tissue trauma and / or up-regulation of nociceptor expression.
Also sustained up-regulation was observed for some genes.
Imiquimod stimulates the immune system through the release and up-regulation of cytokines.
Its up-regulation is an early event under retinal stress conditions.
See also
Studies on rimonabant have shown an up-regulation of adiponectin mRNA in adipose tissue.
Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells.
For example, in some situations cellular activation results in up-regulation of a surface membrane protein.
Comparing the up-regulation of the nucleic acid to matched normal controls.
Epithalon is a peptide used to regulate the cell cycle through up-regulation of telomerase activity.
The extent of up-regulation of such genes can be determined by standard techniques.
Thus, the patient may be subjected to a diagnostic test to detect a marker characteristic of up-regulation.
Up-regulation may be performed by generating protein / enzyme mutants with improved activity.
Hypoxic stress causes a variety of cellular adaptations, often manifesting in the up-regulation of certain genes.
Up-regulation of autophagy is hence considered to have potential therapeutic value in a variety of diseases.
This results in the compensatory up-regulation of NMDA receptors.
Mechanisms of up-regulation include transcriptional activation and the increase in gene copy numbers.
A further adaptive response produced by HIF elevation is up-regulation of cell survival factors.
Both up-regulation and down-regulation of responses of the immune system would be possible.
The PD marker expression profile comprises up-regulation of expression or activity of a set of genes.
Up-regulation of DILPs in aged GSCs and their niche results in increased maintenance and proliferation.
In some embodiments, the agent causes the up-regulation of a MYC gene in a lymphocyte.
Such up-regulation contributes to vascular and cardiac pathophysiology and to drug tolerance to nitrate therapies.
It was concluded that neuropathic pain may be linked to up-regulation of Lyn tyrosine kinase.
Rapid and reversible up-regulation of these molecules allows cells to adhere, detach and migrate.
This co-opted host vasculature in due course showed up-regulation of VEGF and angiogenesis.
Several reports suggest up-regulation of the non-specific barrier function by the products of PUFAs.
LPA exerts many biological effects including activation of platelets and up-regulation of matrix assembly.
This up-regulation lead to the development of a BAT-like phenotype within the white adipose tissue.
In the setting of organ transplant up-regulation of HLA display may also enhance rejection.
Up-regulation of pyruvate dehydrogenase can increase production of acetyl-CoA and thereby increase fatty acid synthesis.
Western blot analysis demonstrated a dose dependent up-regulation of phospho-CHK following DNA damage.
Up-regulation of PGE2 has been implicated as a possible etiology of nail clubbing.
All components of the SAP tested displayed up-regulation within the macrophage cell line used here.
Up-regulation of VEGF has also been observed in various inflammatory disorders.
These findings show that up-regulation of the NO pathway can be protective in AD.
Up-regulation of phosphodiesterase 1A expression is associated with the development of nitrate tolerance.
Depletion of MBNL proteins with siRNAs leads to an up-regulation of MEG3 during myogenesis.
Significant up-regulation of inflammatory cytokines and NO levels have been detected.
Use of these drugs might also be responsible for up-regulation of the D4 receptor.
