Examples of 'variant fc' in a sentence
Meaning of "variant fc"
variant fc - This phrase likely refers to a different or modified version of something, with 'fc' possibly standing for 'variant' or a specific term in a particular context
How to use "variant fc" in a sentence
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variant fc
Identification and engineering of antibodies with variant fc regions and methods of using the same.
The variant Fc heterodimers are generally purified to substantial homogeneity.
Some specific aspects of variant Fc regions are detailed infra.
The variant Fc constant region lacks a hinge region.
Described herein are formulations of proteins comprising a variant Fc region.
Examples of variant Fc regions are detailed herein.
The antibodies of the present invention have variant Fc domains.
Comprises a variant Fc region and has reduced fucosylation or is afucosylated.
In some embodiments is a method of designing bifunctional therapeutics comprising a variant Fc heterodimer.
The variant Fc regions of the present invention may be part of larger molecules.
The present invention provides formulation of proteins comprising a variant Fc region.
Relative binding of variant Fc immunoadhesins to human FcRn as determined by Biacore.
The polypeptides of the present invention may have variant Fc domains.
Variant Fc regions.
The present invention also provides immunoadhesin molecules comprising a variant Fc region.
See also
Said variant Fc region of said polypeptide binds,.
The present invention provides humanized and human antibodies with variant Fc regions.
Comprises a variant Fc region and is aglycosylated or deglycosylated ; or.
Nucleic acid sequences may be mutated such that variant Fc regions may be produced.
Comprises a variant Fc constant region which,.
The Fc region may comprise native or variant Fc sequences.
In certain embodiments, the variant Fc region does not comprise an N-linked glycan.
The Fc domain may comprise native or variant Fc sequences.
Furthermore, a variant Fc region described herein may be utilized to generate an Fc fusión protein.
The Fc region may be a native sequence Fc region or a variant Fc region.
And wherein said variant Fc domain exhibits,.
Monoclonal antibodies The present invention provides monoclonal antibodies with variant Fc regions.
In certain embodiments, the variant Fc region is not glycosylated.
Multispecific antibodies The present invention provides multispecific antibodies comprising a variant Fc region.
In certain embodiments, the FcRn antagonist comprises a variant Fc region linked to a half-life extender.
Fc Domain Variants The polypeptides of the present invention have variant Fc domains.
Moreover, the Fc domain may be a variant Fc domain, as described herein.
Polyclonal Antibodies The present invention provides polyclonal antibodies with variant Fc regions.
Comprises a variant Fc region ; or.
The term includes native Fc regions and variant Fc regions.
In certain embodiments, the variant Fc has increased affinity for CD16a.
An isolated antibody according to claim 3 wherein said Fc domain is a variant Fc domain.
This affinity chromatography step can result in a variant Fc heterodimer preparation that is > 95 % pure.
The multivalent antibody comprises an Fc region e.g. a native sequence or variant Fc region.
BiMabs comprising a variant Fc region are also referred to here as " Fc variant biMabs . ".
In certain embodiments, the amino acid sequence of the variant Fc region is altered.
In preferred embodiments, the variant Fc region containing molecule ( e.g. polypeptide ) is an antibody.
The application further provides ALK1-Fc fusión proteins with engineered or variant Fc regions.
The polypeptide of claim 1, wherein said variant Fc domain of said polypeptide,.
The antibody may be a variant antibody, for example the antibody may comprise a variant Fc domain.
In one embodiment, the Fc region is a variant Fc region.
In some embodiments, the anti-CD38 antibodies of the invention are composed of a variant Fc domain.
In another embodiment, the Fc region is a variant Fc region.
In a particular embodiment, the Fc domain is a variant Fc domain.
In a particular embodiment, the Fc region is a variant Fc region.
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