Examples of 'vismodegib' in a sentence
Meaning of "vismodegib"
relating to a type of medication or treatment
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- A drug for the treatment of basal-cell carcinoma.
How to use "vismodegib" in a sentence
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vismodegib
Effects of vismodegib on concomitant medicinal products.
The active substance is vismodegib.
Vismodegib targets a protein in this pathway.
Erivedge is a cancer medicine that contains the active substance vismodegib.
Vismodegib is embryotoxic and teratogenic in animals.
Dedicated nonclinical studies to evaluate the carcinogenicity of vismodegib have not been performed.
Vismodegib is present in semen.
Thus inhibition of CYP enzymes by vismodegib in vivo may be excluded.
Vismodegib and associated metabolic products are eliminated primarily by the hepatic route.
Patients who have BCC that spreads may be prescribed vismodegib.
The extent to which vismodegib is excreted in breast milk is not known.
Erivedge is an anti-cancer medicine and contains the active substance vismodegib.
Vismodegib is slowly eliminated by a combination of metabolism and excretion of parent drug substance.
Clinically significant PK interactions between vismodegib and pH elevating agents are not expected.
Vismodegib attaches to a.
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In particular, caution should be exercised if vismodegib is administered in combination with any statin.
Vismodegib binds to and inhibits the SMO protein thereby blocking Hedgehog signal transduction.
Upon continuous daily dosing, there is a 3 fold accumulation of vismodegib total plasma concentrations.
No increases in plasma vismodegib levels or toxicity were observed during these clinical trials.
What Erivedge is Erivedge is an anti-cancer medicine and contains the active substance vismodegib.
Metabolic pathways of vismodegib in humans include oxidation, glucuronidation, and an uncommon pyridine ring cleavage.
Clinically significant PK interactions between vismodegib and P-gp inhibitors are not expected.
In one preferred embodiment, the Hedgehog Pathway Inhibitor comprises vismodegib.
The major elimination pathways of vismodegib involve hepatic metabolism and biliary / intestinal secretion.
Vismodegib binds to both human serum albumin and alpha-1-acid glycoprotein AAG.
CYP2C9 appears to contribute in part to vismodegib metabolism in vivo.
Vismodegib attaches to a protein called ‘ SMO ', which is involved in activating the Hedgehog signalling pathway.
Under clinically relevant conditions ( steady state ), the PK of vismodegib is not affected by food.
Vismodegib is predominant in plasma, with concentrations representing greater than 98 %.
Clinically significant PK interactions between vismodegib and CYP450 inhibitors are not expected.
In vitro, CYP2C8 was the most sensitive CYP isoform for vismodegib inhibition.
In vitro, vismodegib is an inhibitor of OATP1B1.
Each hard capsule contains 150 mg of vismodegib.
Clinically significant PK interactions between vismodegib and CYP450 substrates are not expected.
