Examples of 'vwf' in a sentence
Meaning of "vwf"
vwf - (noun) stands for Von Willebrand Factor, a glycoprotein in blood plasma that is essential for the clotting process. It plays a crucial role in hemostasis and is involved in various blood-related disorders and diseases
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- Initialism of von Willebrand factor.
- Initialism of vibration white finger.
How to use "vwf" in a sentence
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vwf
Platelets store vWF in their alpha granules.
Treatment of coagulation disease by administration of recombinant vwf.
Serum vWF levels were measured by two different methods.
The first determined absolute serum vWF levels.
The vWF is quantitatively normal but qualitatively defective.
There was no closure due to the lack of normal vWf.
Bound vWF was detected as described before.
Selected sections are stained for the presence of vWF.
At present vWF is the largest known plasma protein.
Therefore the platelets tend to be saturated with vWf.
The interaction of vWf is essential for normal hemostasis.
The second method used determined relative serum vWF activity.
One study demonstrated that vWF activity is increased in smokers.
Large vWF multimers are reduced or absent from the circulation.
Reduced vWF activity.
See also
The role of vWF.
There was no change in vWF gene expression before and after irradiation.
It has been designed to inhibit the interaction between vWF and platelets.
The complexity of the vWF molecule makes it very difficult to purify.
The therapy constrains the interface between vWF and platelets.
The biological activity of vWF can be measured by known in vitro assays.
The intention was to generate peptides with high affinity for vWf.
Recombinant vWF can be produced by expression in a suitable eukaryotic host system.
Method of producing recombinant high molecular weight vWF in cell culture.
Mutant vWF cDNA fragments may also be cloned in eucaryotic host cells.
Specific testing involves sending blood samples to have vWF measured.
Recombinant vWF or variants thereof can be conveniently prepared using standard protocols.
Fragments can include truncated forms of the vWF cleaving protease.
Also provided are vWF polypeptides and nucleic acid molecules encoding same.
The absence of aggregation may indicate vWf deficiency as the cause.
The vWF binder was demonstrated to be robust after lyophilization to extremes in product temperature.
It is therefore desirable to have a method for rapid indication of vWf deficiency.
Providing low levels of vWF in a patient is suggested to be protective for such diseases.
Three forms of the disease are distinguished based on vWF concentration and function.
Whether cargo besides vWF is exocytosed from secretory pods or selectively retained is uncertain.
Gene sequencing identified many of these persons as having a vWF gene mutation.
The vWF fragment exhibited extreme insolubility following lysis of either population of cells.
Electrophoresis can be used to confirm that the vWF is still in multimeric form.
All the vWF binders mentioned above are well known from the literature.
Any preparation known in the art containing vWf is useful in the assay.
The circulating vWF molecule ranges in size from dimers to extremely large multimers.
Thrombin triggers the binding of the adhesive platelets with vWF and fibrinogen.
The vWF can be added separately to the culture medium and is preferably recombinant.
This rapid turnaround obviates the delay seen in prior art vWf tests.
The eluted vWF may then be further purified using additional chromatography steps.
A single isolate from this transformation was then used for expression of vWF fragment.
The vWF antigen present in the sample binds to the antibody on the microtiter plate.
Several novel inhibitors which prevent platelet adhesion are monoclonal antibodies directed to vWF.
Unaggregated alkylated vWF fragment represents the combined concentration of the monomer and dimer.
Suitable formulations can be identified by assaying one or more parameters of vWF binder integrity.
