Examples of 'wortmannin' in a sentence
Meaning of "wortmannin"
wortmannin (noun): Wortmannin is a potent and selective inhibitor of phosphoinositide 3-kinases (PI3Ks), enzymes involved in cell growth, proliferation, and survival signaling pathways. It is commonly used in research to study PI3K-related cellular functions and has potential therapeutic applications in cancer and other diseases
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- A furanosteroid metabolite of the fungus Penicillium funiculosum; it is an inhibitor of some kinases
How to use "wortmannin" in a sentence
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wortmannin
Attempts to synthesize derivatives of wortmannin have so far been problematical.
Wortmannin has been indicated in the treatment of neoplastic conditions.
One of the disadvantages of wortmannin is its toxicity to living creatures.
Wortmannin may be further manipulated to arrive at the compounds of the present invention.
Further controls will be performed for inhibition of protein association with wortmannin and rapamycin.
Small quantities of wortmannin may be obtained by shakeflask culture.
Figure 3 illustrates the structure of certain other wortmannin analog structures ;.
Following fermentation wortmannin is extracted and purified vÃa known methods.
In addition, downstream effector polypeptides can be inhibited by other compounds such as wortmannin.
Formulation of wortmannin analogs is well known in the art as is the fermentation process.
In contrast, irradiation in the presence of wortmannin had only a modest effect.
The wortmannin analogs of the present invention are expected to be useful in treating restenosis.
The present invention provides for the use of wortmannin and certain analogs as restenosis inhibitors.
Wortmannin served as control compound for the mTOR kinase activity assay.
HPLC analysis of this wortmannin showed a more polar impurity.
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Wortmannin can be recovered using various isolation and purification procedures understood in the art.
Treatment of neutrophils with wortmannin prevents the fMLP-induced respiratory burst response.
Wortmannin is one of the most well-known specific inhibitors.
In the case of indirectly acting compounds, agents such as insulin and wortmannin are excluded.
The clinical uses of wortmannin and its many derivatives are limited by its substantial toxicity.
The plate was read on Cellomics and the IC50 values were calculated compared to Wortmannin.
Composition comprising wortmannin and its topical use for reducing human hair growth.
Lymphocytopenia is expressed as the percent decrease in lymphocyte counts relative to wortmannin as 1.0.
Typically, wortmannin can be recovered from the biomass by a variety of techniques.
FIG . 2 illustrates formulas for comparative wortmannin analog and metabolite structures.
Wortmannin demonstrates liver and hematologic toxicity, however, and is a biologically unstable molecule.
Figure 2 illustrates the structure of certain wortmannin analog structures in accordance with the present invention ;.
Wortmannin inhibits PI3 kinase by binding irreversibly to its catalytic subunit.
Figure 2 illustrate certain other wortmannin analogs and Figure 3 illustrates certain other wortmannin analogs.
Wortmannin may optionally be used in embodiments disclosed herein as a PI3K inhibitor.
These results demonstrate that wortmannin over-rides the DNA damage G2 checkpoint in HeLa cells.
Wortmannin interacts with many biological targets, but binds in vitro most strongly to PI3 kinase.
CytochalasinB, bovine insulin and Wortmannin were from Sigma.
Even in low dosages, wortmannin in pure form was often lethal to laboratory animals.
The protective effect of MPE-001 was completely abolished by the autophagy inhibitors wortmannin and bafilomycin A1.
The impact of wortmannin on the HeLa and Saos2 cells is analyzed.
The cytotoxicity of the metabolites of wortmannin analogs is shown in FIG . 8.
Most wortmannin and its derivatives are potent PI3 kinase inhibitors.
Other inhibitors of PI3K include PP2 and wortmannin.
Inhibition of PI3K activity by wortmannin eliminates the subsequent cellular response to the extracellular factor.
Figure 7 illustrates the effect on Weight Loss by Wortmannin and Analogues ;.
Treatment of neutrophils with wortmannin prevents the fMLP-induced respiratory burst response Thelen et al.
Figure 4 Shows glucose transport effect of Compound 13 or 15 in the presence or absence of wortmannin.
Wortmannin is a selective inhibitor of PI3 Kinase and inhibits insulin-stimulated glucose transport.
A composition was prepared comprising wortmannin at 10 milli-molar in a vehicle of dimethyl sulfoxide ( DMSO ).
The wortmannin analogs are the wortmannin analogs described in Figs 1 and 2, preferably Fig . 1.
Figure 1 illustrates the structure of the wortmannin analog DJM2-167 in accordance with the present invention ;.
The effects of wortmannin on the radiation-induced inactivation of Cdc25 was then tested.
Figures 1 illustrates the specific structure of wortmannin analog DJM2-167 in accordance with the present invention.
Compound 1, 2 or wortmannin are incubated with mTOR enzyme for 30 minutes on ice.
