Examples of 'y-secretase' in a sentence
Meaning of "y-secretase"
y-secretase (noun): An enzyme involved in the processing of certain proteins, particularly in the field of molecular biology and neuroscience
How to use "y-secretase" in a sentence
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y-secretase
Y-secretase cleavage sites are indicated above the sequence by arrows.
The compounds of the present invention are Y-secretase modulators.
However further Y-secretase modulators would be desirable.
There is however a need for further Y-secretase modulators.
Processing of y-secretase was monitored by quantifying the secretion of AB into the culture medium.
This is consistent with its function as a component of Y-secretase.
The complete molecular identity of Y-secretase enzyme is still unknown.
Operationally, an inhibitor or a modulator is defined as compound which lowers AB through Y-secretase.
Therefore these tumors fail to respond to Y-secretase inhibitors treatment.
Conversion of the Y-secretase peptide substrate was not detected under these reaction conditions.
This was subsequently confirmed by treatment with specific Y-secretase inhibitors.
A recently discussed mechanism of y-secretase cleavage implies sequential proteolytic cleavage steps to release AB.
The compounds can be used for modulation of Y-secretase activity.
The Y-secretase is a proteolytic activity consisting of several proteins, its exact composition is incompletely understood.
It must additionally be cleaved by the Y-secretase in order to release the AB-peptide.
See also
In one embodiment, factor that inhibits the Notch signaling pathway is a Y-secretase inhibitor.
The incubation of these cultured cells with Y-secretase inhibitors decreases the production of AB peptides.
It can be used to monitor the interaction of these substrates with the Y-secretase enzyme.
Compounds that specifically target Y-secretase could reduce or prevent age-related macular degeneration.
Western blot showing the cleavage of NusA-Notch fusión using solubilized Y-secretase.
The above solubilized fraction is used in the Y-secretase assays described herein throughout.
Such a method is useful in the present invention for providing a purified fraction containing a Y-secretase.
The characteristics of Y-secretase activity described were confirmed using more than five independent membrane preparations.
There is a further need to find compounds which have Y-secretase inhibitory activity.
The composition comprising Y-secretase activity would generally be any isolated composition that comprises a Y-secretase activity.
It has been found that the compounds of the present invention modulate the Y-secretase activity.
The cells were co-cultivated with the Y-secretase inhibitor and monitored the changes in luciferase activity.
Third, samples were assayed from animals that were treated with high doses of a Y-secretase inhibitor.
Y-Secretase plays a pivotal role in the Notch activation cascade.
Preferably, such a membrane fraction contains all the components needed for the Y-secretase complex.
The effects of Y-secretase inhibitors in reducing brain AB have also been investigated.
These patients should be identifiable with amyloid imaging agents and potentially treatable with Y-secretase inhibitors.
The Y-secretase activity is absolutely required for the production of AB peptides.
APP is cleaved in the transmembrane region by Y-secretase.
Compounds that specifically target Y-secretase could reduce or prevent IBM.
The latter is believed to give rise to AB peptides following cleavage by Y-secretase.
Compounds that specifically target Y-secretase could reduce or prevent CAA.
The Y-secretase activity is absolutely required for the production of Abeta peptides.
Alternatively, the Notch dependent cancer is resistant to Y-secretase inhibitor treatment.
Y-Secretase activity is required for signaling by the Notch family of transmembrane receptors.
In the list below are described some data to the Y-secretase inhibition, Example No.
The Y-secretase cleaves at variable sites thus generating AB peptides of varying lengths.
Field of the Invention The present invention is directed to novel soluble substrates for Y-secretase.
Modulators of Y-secretase derived from compounds of Formula I can be delivered vía a controlled release system.
Specifically, presenilin is an essential for Y-secretase activity.
Y-secretase activity is reduced 80 % in cultured cells derived from embryos genetically deleted for presenilin 1.
Compounds were scored as active Y-secretase inhibitors if Ki values were less than 10 µM.
Y-Secretase activity is enriched in autophagic vacuoles and it augments amyloid-B ( AB ) synthesis.
A decrease in luciferase activity reflects a decrease in Y-secretase activity . References,.
The Y-secretase activity can also be determined in a cellular assay where e . g.
