Examples of 'allosteric modulators' in a sentence
Meaning of "allosteric modulators"
Allosteric modulators are substances or compounds that bind to a specific site on a protein or enzyme, altering its activity. These modulators can enhance or inhibit the activity of the protein or enzyme, leading to a variety of physiological effects. They are commonly used in pharmaceutical research and drug development
How to use "allosteric modulators" in a sentence
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allosteric modulators
Such targets are called allosteric modulators.
The use of allosteric modulators provides several advantages in the treatment of disease.
Compounds that function as allosteric modulators are also known.
Positive allosteric modulators can potentiate effects by enhancing the efficacy and or potency of agonists.
Allosteric agonists are to be distinguished from pure allosteric modulators.
Ampakine stimulants are allosteric modulators of AMPA receptors in the brain.
Described in the prior art are positive allosteric modulators.
Allosteric modulators of GABAA receptors.
The mechanism of action of positive allosteric modulators is so far unclear.
The two species of the Leptomitales examined were completely insensitive to the allosteric modulators.
A typical feature of FGFR allosteric modulators is their inability to compete with FGF binding.
Morpholinothiazoles as alpha 7 positive allosteric modulators.
Ago-allosteric modulators are both allosteric agonists and allosteric modulators.
Within the complex protomers act as allosteric modulators of another.
Allosteric modulators of mGluR5 have emerged recently as novel pharmaceutical entities offering this attractive alternative.
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These calcimimetic compounds can also be considered allosteric modulators of the calcium receptors.
At present, no selective allosteric modulators of the M4 subtype of muscarinic receptor have been reported.
Various compounds have been described as mGluR2 positive allosteric modulators.
There is a scarcity of selective allosteric modulators for the mGluR5 receptor.
More generally, these differences in phosphorylation can be used as reporter to evaluate allosteric modulators.
Further preferred a7-nAChR positive allosteric modulators cross the blood brain barrier effectively.
The activating compounds can in particular be agonist compounds, partial agonists or positive allosteric modulators.
The most preferred indications for compounds which are allosteric modulators are schizophrenia and cognition.
Examples of allosteric modulators were described for the mGluR subtype 4 ( mGluR4 ).
The compounds provided in the present invention are positive allosteric modulators of mGluR5.
In one group of embodiments, the allosteric modulators can destabilize one conformation while stabilizing another.
Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors.
It will also identify allosteric modulators of μ-opioid plus nociceptin / orphanin FQ receptors.
In particular, the binding domains described herein can be allosteric modulators or allosteric inhibitors.
Domain Therapeutics discovers allosteric modulators by exploiting its innovative and proprietary DTect-All ( TM ) technology.
PHARMACOLOGY, The compounds provided in the present invention are positive allosteric modulators of mGluR5.
The compounds of this invention are allosteric modulators of metabotropic glutamate receptors ( mGluR ), particularly, mGluR2.
Pharmacological examples The compounds provided in the present invention are positive allosteric modulators of mGluR2.
Preferred a7-nAChR positive allosteric modulators should be non-toxic and demonstrate few side-effects.
More particularly, the compounds of the invention are positive allosteric modulators of the GABAA channel.
Another antagonist or allosteric modulators of CB 1 cannabinoid receptors ;.
Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators.
The purpose of my study was to characterize positive allosteric modulators on alfa7 nicotinic receptor.
Pyranyl aryl methyl benzoquinazolinone M1 receptor positive allosteric modulators.
A third class of drugs would correspond to the allosteric modulators of the GLP-1 receptor.
The high-affinity receptor state requires both Mg ( 2 + ) and cholesterol, which probably function as allosteric modulators.
The compounds of the invention are positive allosteric modulators of the muscarinic M1 receptor.
The so-called benzodiazepine ( BZD ) receptor is a site for such allosteric modulators on the GABA-A receptor.
The assay was used to identify positive allosteric modulators ( PAMs ) of the a7 receptor.
The main difference between positive - and negative allosteric modulators can be seen in FIG.
Another cannabinoid CB 1 receptor antagonist or allosteric modulators of cannabinoid CB 1 receptors ;.
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