Examples of 'antigen-binding protein' in a sentence
Meaning of "antigen-binding protein"
antigen-binding protein: This term refers to a protein that specifically binds to antigens, such as those found on pathogens or foreign substances. These proteins play a crucial role in the immune response by helping to detect and neutralize potentially harmful invaders in the body
How to use "antigen-binding protein" in a sentence
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antigen-binding protein
The antigen-binding protein may be an antibody.
A method of producing a multivalent antigen-binding protein comprising the steps of,.
The antigen-binding protein with desired characteristics may be purified.
A method of producing a multivalent antigen-binding protein characterised in that it comprises,.
Haptenylated probes are preferably detected by use of an anti-hapten antigen-binding protein.
Any suitable antigen-binding protein may be utilized.
In a specific embodiment, the human is a human being treated with the antigen-binding protein.
Detection of antigen-binding protein complexes may be qualitative and / or qualitative.
The present invention is directed to the above method of producing a multivalent antigen-binding protein.
An antigen-binding protein for use according to the invention is as defined in the claims.
Also provided is a composition comprising a multivalent antigen-binding protein substantially free of single-chain molecules.
An antigen-binding protein according to any preceding claim which is specific for a tumour-associated antigen.
The pellet containing the insoluble antigen-binding protein was retained, and the supernatant was discarded.
Also included are gentic constructions coding for this multivalent single-chain antigen-binding protein.
The specificity of an antigen-binding protein can be determined based on affinity and / or avidity.
See also
Also well-known in the art are methods and conditions for detecting antigen-binding protein complexes.
A preferred form of the multivalent antigen-binding protein comprises bivalent proteins, including heterobivalent and homobivalent forms.
There is also possible a DNA sequence encoding a bispecific bivalent antigen-binding protein.
A heterobivalent antigen-binding protein has two different binding sites, the sites having different binding specificities.
The invention also includes a DNA sequence encoding a bispecific bivalent antigen-binding protein.
A method of producing a VL antigen-binding protein that specifically binds a steroid comprising the steps of,.
In some embodiments, the enzyme is conjugated to an antigen-binding protein.
In one embodiment, the antigen-binding protein is an antibody.
The antigen-binding protein of any one of claims 1 to 4 conjugated to a therapeutic agent.
FIG . 6B is a schematic depiction of a hypothetical tetravalent antigen-binding protein according to the Rearrangement model.
In one aspect, the antigen-binding protein displays pH-dependent antigen binding properties.
The method of claim 16 wherein recovering said multivalent antigen-binding protein comprises,.
A kit comprising an antigen-binding protein of any one of claims 1 to 6.
The factor XI-binding protein of the invention preferably is a mono-specific antigen-binding protein.
In various aspects, the antigen-binding protein is an antibody.
An antigen-binding protein according to claim 1, wherein the linker molecule is a maleimide cross-linker.
Coli protein as antigen-binding protein.
The antigen-binding protein can be directed against the extracellular domain of HER-3.
In a specific embodiment, the antigen-binding protein is an antibody.
Example 6 demonstrates the construction of a DNA sequence coding for a bivalent single-chain antigen-binding protein.
In one case, the antigen-binding protein is a human antibody.
FIG . 2C depicts a hypothetical tetramer of four single-chain antigen-binding protein molecules.
In one aspect, the antigen-binding protein is a human protein.
The plurality of microparticles of claim 10 or 11, wherein the protein is an antigen-binding protein.
In one embodiment, the antigen-binding protein is a human protein.
The antigen-binding protein of claim 1 or claim 2, wherein the antigen-binding protein is fully human.
The method of claim 6, wherein the antigen-binding protein is an antibody.
The single-chain antigen-binding protein molecules are shown binding antigen in their antigen-binding sites.
To produce this result, 60 % of the mRNA must be translated into fully functional antigen-binding protein.
In one embodiment, the antigen-binding protein is an antibody of IgG1 isotype.
This production system produced between 2 and 20 % of the total E. coli protein as antigen-binding protein.
An isolated nucleic acid that encodes an antigen-binding protein of any one of claims 1 to 4.
The antigen-binding protein that binds to HER-3 can be an antibody.
Separating said multivalent antigen-binding protein from said single-chain molecules and / or,.
An antigen-binding protein according to claim 13, wherein said tumour-associated antigen is CEA.
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