Examples of 'antisense sequence' in a sentence
Meaning of "antisense sequence"
antisense sequence - In molecular biology, an antisense sequence is a DNA or RNA sequence that is complementary to a specific mRNA sequence. It acts by binding to the mRNA and inhibiting its ability to be translated into proteins, thereby regulating gene expression
How to use "antisense sequence" in a sentence
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antisense sequence
Composition comprising an antisense sequence implicated in the regulation of angiogenesis.
Improved antisense suppression is typically observed as the length of the antisense sequence increases.
The antisense sequence may be exactly complementary to the target sequence.
The NOI may be a sense sequence or an antisense sequence.
The antisense sequence advantageously comprises at least twelve contiguous nucleotides or their derivative.
The length of the CAG antisense sequence seems critical.
An antisense sequence to an expression sequence of a nucleotide sequence according to claim 1 or claim 6.
The NOI may even be an antisense sequence for any of those sequences.
The composition of claim 1, wherein the nucleic acid comprises an antisense sequence.
Targeting the natural antisense sequence modulates the function of the target gene.
Thus, the agent may be an antisense sequence.
Targeting the antisense sequence preferably modulates the function of the target gene.
Within another embodiment of the invention, the heterologous sequence is an antisense sequence.
Hybridization between the antisense sequence and corresponding region of the pest gene sense strand.
The sequence of the polynucleotide can consist essentially of, or is, the antisense sequence.
See also
First, the antisense sequence expressed in the transformed cell is unstable.
The target gene sequence encodes at least part of, a functional protein or an antisense sequence.
In this case, the antisense sequence is contained within a polynucleotide of longer sequence.
More particularly, the biologically active nucleic acid molecule may be an antisense sequence.
A candidate antisense sequence is prepared as provided herein, using standard chemical techniques.
For the first strand cDNA synthesis, primers with an antisense sequence are used.
In certain cases, the antisense sequence is exactly complementary to the target sequence.
In one embodiment, the sequence of the polynucleotide contains within it the antisense sequence.
In certain embodiments, the antisense sequence is exactly complementary to the target sequence.
Thus, the desired polynucleotide may comprise a sense and antisense sequence of a leader sequence.
Generally, the antisense sequence will have the same species of origin as the animal host.
In such a case, only one or two bases of the antisense sequence may be changed.
An efficient antisense sequence according to the invention is capable of hybridizing with the U7 loop.
Thus, in a preferred embodiment, the desired polynucleotide comprises a sense and antisense sequence of a leader sequence.
In our example, that antisense sequence would be UUCCAG.
In reality, either one of the genomic DNA and each probe is an antisense sequence.
In contrast, treatment with the antisense sequence from document Hatzfeld et al.
The template polymer is a nucleic acid including DNA, RNA or an antisense sequence.
Short synthetic antisense sequence complementary to the R2 sequence also provided increases sensitivity.
An interaction by hybridization between the antisense sequence and the U7 loop is required.
The method according to Claim 6 or 7, wherein the antagonist is an HMG1 gene antisense sequence.
The compound comprises the antisense sequence present in Tables A 1.
The antisense sequence can be a DNA, and RNA e . g.
An antagonist as claimed in Claim 1, which is an HMG1 gene antisense sequence.
Preferably, the antisense sequence is at least 20 nucleotides in length.
One cassette harbors the 21-nt sense sequences and the other a 21 nt antisense sequence.
However, it is possible to use an antisense sequence which differs in length by about 10 %.
The antisense sequence can be DNA, RNA, or any nucleic acid mimic or analog.
A polynucleotide comprising the sense or antisense sequence of SEQ ID NO, 8, or a complement thereof ;.
Use as claimed in Claim 10, wherein the antagonist is an HMG1 gene antisense sequence.
Preferably, the length of the antisense sequence in the vector will be greater than 100 nucleotides.
The pharmaceutical composition of Claim 5, wherein component ( a ) is an HMG1 gene antisense sequence.
For example, a natural antisense sequence of HBF comprises SEQ ID NO, 2 and variants thereof.
For preferred embodiments, the antisense sequence is less than 100 nucleotides.
For example, an antisense sequence can be from about 100 nucleotides to about 1 kb in length.
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This simultaneously establishes an efficient work sequence
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Examples of using Antisense
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Antisense RNAs can be classified in different ways
In a separate embodiment new antisense oligodeoxynucleotides are provided
Antisense polynucleotides can include deoxyribonucleotides or ribonucleotides
