Examples of 'b-lactamase' in a sentence
Meaning of "b-lactamase"
b-lactamase (noun) - An enzyme produced by certain bacteria that confers resistance to β-lactam antibiotics, such as penicillin and cephalosporins, by breaking down the β-lactam ring of these drugs
How to use "b-lactamase" in a sentence
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b-lactamase
B-lactamase activity was detected with the nitrocefin test.
For the combination therapy, some of the antibiotics may further be used with a B-Lactamase inhibitor.
The bacteria produced b-lactamase s capable of degrading all the b-lactamic drugs.
Other preferred antimicrobial agents are B-lactamase inhibitors.
B-lactamase activity will often be measured in relation to a reference sample, often a control.
The treatment may be by B-lactamase inhibition.
B-lactamase cleaves the substrates and relieves the stacking, allowing for fluorescence.
Such sequences improve expression of B-lactamase in mammalian cells.
B-lactamase in the lactic acid bacterium Lactococcus lactis.
Another object of the invention is to provide B-lactamase reporter genes.
Chymotrypsin or B-lactamase do not react with the salmycins.
They have high potency as antibiotics and B-lactamase inhibitors.
A preferred B-lactamase inhibitor is clavulanic acid, preferably as potassium clavulanate.
Ampicillin is also available in combination with sulbactam, a B-lactamase inhibitor.
The amount of B-lactamase activity in the medium was steroid dependent.
See also
A pharmaceutical composition as claimed in claim 6 further comprising a B-lactamase inhibitor.
B-Lactamase catalyzed hydrolysis of this compound generates two fluorescent fragments.
This suggests that these drugs are insensitive to B-lactamase mutations.
The B-lactamase may be contacted with the compound of claim 1 in vitro or in vivo.
This also permits multiplying based on directed localization of B-lactamase.
This resistance is usually attributable to the B-lactamase produced by the microorganism.
In one embodiment it is preferred that the heterologous protein is not B-lactamase.
The antibiotic which is studied when the B-lactamase is used is amoxicillin.
The assay is initiated by addition and mixing of an appropriate amount of B-lactamase.
The formulation may additionally contain a B-lactamase inhibitor such as potassium clavulanate.
Amoxicillin is also available in combination with clavulanic acid, a B-lactamase inhibitor.
A method of determining the amount of B-lactamase activity in a cell comprising the steps of,.
The amount of substrate cleaved is related to the amount of B-lactamase activity.
B-Lactamase inhibitors having various chemical structures have been developed thus far.
Preferably, FRET is used as a way of monitoring B-lactamase activity inside a cell.
It is another object of the present invention to provide methods of inhibiting a B-lactamase.
Second, the B-lactamase gene of the pUC plasmids was chosen as a selection marker.
It also tends to be resistant against inactivation by bacteria that produce B-lactamase.
Such compositions of this invention comprising a B-lactamase inhibitor are formulated in conventional manner.
Thus B-lactamase expression in blood is a strong indicator of whether a chicken was successfully transduced.
The coupling of the biotinylated B-lactamase and antibodies is made by use of streptavidine.
The B-lactamase encoded can be any known to the art or described herein.
Accordingly, one object of the present invention is to provide novel B-lactamase inhibitors.
Representative B-lactamase inhibition test results for inhibitors of the invention are shown in Table 3.
In a particular embodiment the proton releasing enzyme mediator comprises a B-lactamase enzyme.
In some embodiments, more than one B-lactamase inhibitor may be administered sequentially or simultaneously.
In one embodiment, the engineered fluorescent protein is used in a substrate for B-lactamase.
If the other antibacterial is a B-lactam then a B-lactamase inhibitor may also be employed.
The B-lactamase inhibitors are used along with B-lactam antibiotics to promote the antibiotic activity.
All the test strains used in the above assays were B-lactamase producers.
The currently available B-lactamase inhibitors are insufficient to counter the constantly increasing diversity of B-lactamases.
Compounds of this invention can exhibit antibiotic activity and / or B-lactamase inhibition.
The second strategy has been the use of B-lactamase inhibitors in combination with B-lactam antibiotics.
In some assays, the fluorogenic substrate is converted to a fluorescent product by B-lactamase activity.
The level of B-lactamase enzyme activity was measured by fluorescence resonance energy transfer ratiometric detection.
