Examples of 'c-kit' in a sentence
Meaning of "c-kit"
C-kit (noun): A receptor tyrosine kinase protein involved in cell signaling. This term is commonly used in molecular biology and medicine
How to use "c-kit" in a sentence
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c-kit
Mutations in c-kit and PDGFrA are mutually exclusive.
A mutation may be in any part of the c-KIT gene.
C-kit is also expressed on mesenchymal stem cells.
Reports of expression of c-Kit in normal astrocytes have been made.
In some aspects of the disclosure mutations in c-KIT are determined.
Mutations in c-Kit have been implicated in human disease.
This invention further provides c-kit ligand antagonists.
Activation of c-kit induces eosinophil activation and degranulation.
Screening for inhibitors or modulators of c-KIT.
Aberrant c-kit signaling is believed to be a mediator of certain autoimmune diseases.
The following section discusses immunological detection of c-Kit.
The association of c-kit with astrocytoma pathology is less clear.
In some embodiments mutations in c-KIT are determined.
Compounds of the invention are effective for the inhibition of c-KIT.
Inhibitors of c-Kit can be administered to a patient for the treatment of melanoma.
See also
These miRNAs were found to target the oncogene c-Kit.
Expression of c-Kit has also been observed in normal human brain tissue.
Compounds of the present invention were found to inhibit c-KIT.
Thus, c-kit is a useful target in treating neurofibromatosis as well as malignant tumors.
The probes used in such applications specifically hybridize to c-KIT.
Expression of c-Kit has been observed in glioblastoma cell lines and tissues.
Example of cell lines expressing an activated-mutant c-kit are as mentioned above.
Therefore, inhibition of c-kit will be useful in the treatment of the above disorders.
Such assays are often performed with cells that overexpress c-Kit.
Aberrant expression and / or activation of c-Kit has been implicated in a variety of pathologic states.
In general, compounds of the invention are effective for the inhibition of c-KIT.
Therefore, inhibition of c-kit kinase provides a means for treating these disorders.
Canine mast cell tumour growth is frequently driven by an activating mutation in c-Kit.
Compounds of the invention are expected to induce c-kit degradation in a dose-dependent manner.
The lymph nodes were evaluated by histopathology, histochemistry and immunohistochemistry with c-kit.
The presence of a mutated tyrosine kinase c-kit receptor must be confirmed prior to treatment.
By way of example only, these compounds are potent and selective c-kit inhibitors.
Mutation of c-Kit tyrosine kinase is associated with decreased survival in gastrointestinal stromal tumors.
These antisense molecules would block the translation of c-kit ligand in vivo.
The effect of c-KIT knock down on thrombin-induced drop in normalized endothelial resistance.
In some examples, described are methods for treating a disease or condition modulated by c-kit.
The c-kit receptor kinase has been associated with such cell proliferative disorders.
For the positive control was 4 used a positive mastocytoma sample for c-kit expression.
A C-Kit kinase inhibitor for use in the treatment of gastrointestinal stromal tumor or mastocytosis.
Lesser numbers of GISTs appear to be associated with neither c-kit nor PDGFR-α abnormalities.
The presence of c-kit has also been associated with a number of different types of cancers.
These could be small molecule antagonists found by screening assays on the c-kit receptor.
Immunohistochemical analysis of c-Kit protein expression further supports its role as a melanoma oncogene.
The methods employed are the same as those used to determine sequence mutations in c-Kit.
After a literature search, c-kit was identified as a candidate marker for presumptive melanocyte precursors.
The present invention provides a tool for the isolation of c-kit expressing cells.
Similarly, immunocompromised c-Kit mutant mice can be engrafted by human HSCs without any irradiation.
An humanized aglycosylated IgG1 antibody that specifically binds c-Kit and that comprises.
Therefore, inhibition of c-kit kinase will prove useful in the treatment of the above disorders.
Cell lines naturally expressing and depending on c-kit for growth and survival.
