Examples of 'cell epitopes' in a sentence
Meaning of "cell epitopes"
Cell epitopes are specific regions on the surface of a cell or a molecule that can be recognized and targeted by the immune system. They play a crucial role in immune responses and can be used in various applications, such as vaccine development or disease diagnosis
How to use "cell epitopes" in a sentence
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cell epitopes
T cell epitopes are also suitable carrier molecules.
The composition of the present invention may comprises a plurality of T helper cell epitopes.
T cell epitopes can be identified by a number of different methods.
The peptides of the invention were selected as potential T cell epitopes through in silico methods.
B cell epitopes could be identified in the TNFa both theoretically and experimentally.
This method can allow the identification of T cell epitopes that are processed by the immunoproteosome.
T cell epitopes of MOMP have also been investigated.
Many rules have been developed for predicting the amino acid sequences of T cell epitopes.
Said T cell epitopes may also be bound to a carrier vÃa a or without a linker.
Therefore the alpha and beta chains were designed to include these relevant T cell epitopes.
B cell epitopes were mapped by ELISA using the panel of synthetic peptides.
These epitopes are preferably selected from the group consisting of cytotoxic and Th cell epitopes.
Peptides comprising T cell epitopes may be prone to the formation of dimers in solution.
These findings suggest antigenic cross reaction of the T cell epitopes of bee and vespid hyaluronidases.
Cytokines and T cell epitopes represent a small number of these candidate genes or gene fragments.
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Reagents that detect presentation of particular T cell epitopes from target antigens can also be used.
T cell epitopes differ fundamentally from B cell epitopes.
Location and content of T cell epitopes are determined empirically.
The T cell epitopes described herein can be modified to increase immunogenicity.
According to a preferred embodiment T cell epitopes are used as antigens.
By this means a polypeptide is used which incorporates several T cell epitopes.
By removal of the T cell epitopes the antibody is less immunogenic.
Both of these are strategies for identifying the possible and best B cell epitopes.
The molecules lacking T cell epitopes are useful as analogs in the invention.
The inserted sequence may also include one or more B cell epitopes of interest.
The existence of T cell epitopes other than those indicated above is not excluded.
Other potential low to very low immunogenic T cell epitopes were also identified.
Some T cell epitopes are promiscuous while other T cell epitopes are universal.
Broad range antigenic helper T cell epitopes are known in the art.
This software provides means for the qualitative and quantitative prediction of T cell epitopes.
B cell epitopes of a protein are of two types, topographic and linear.
This type of epitope analysis has allowed the definition of T cell epitopes present in TRFP.
In general, B cell epitopes of antigens are longer, and are known as conformational epitopes.
These approaches entail carrying out substitutions of amino acids within potential T cell epitopes.
T cell epitopes of the Cyn d 1 allergen from bermuda grass pollen.
The invention provides for modified antibodies with one or more T cell epitopes removed.
According to one embodiment, all T cell epitopes are removed from the immunoglobulin variable domains.
The latter known HCV polypeptides and peptides are described for screening for B cell epitopes.
Preferably, said peptide comprises at least two T cell epitopes specific for said antigen.
A composition as claimed in claim 2 in which the composition comprises a plurality of T helper cell epitopes.
Shorter B cell epitopes are preferred, to facilitate peptide synthesis.
Computer programs are also available for identifying B cell or T cell epitopes.
Therefore, helper T cell epitopes generally represent foreign protein fragments.
It is within the capabilities of the skilled person to identify B and T cell epitopes.
For example, potential T cell epitopes are usually biased towards the CDRs.
The composition according to claim 6, wherein the plurality of T helper cell epitopes are combined.
The HLA-A2 restricted killer T cell epitopes identified in the present invention are underlined.
In various aspects of the invention, the antigen contains one or more T cell epitopes.
Other epitopes can be B cell epitopes which stimulate production of epitope-specific antibodies.
Furthermore, another twenty peptides were identified as good t cell epitopes in a publication by our group.
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