Examples of 'chimeric molecule' in a sentence
Meaning of "chimeric molecule"
chimeric molecule - a scientific term referring to a molecule composed of different types of genetic material or sections combined together
How to use "chimeric molecule" in a sentence
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chimeric molecule
Such a chimeric molecule can be synthesized chemically or recombinantly.
Conjugated compositions may be synthesized as a chimeric molecule directly by solid phase synthesis.
The chimeric molecule is internalized into the cell.
Binding of the antibody to the mimotope reduces the activity of the chimeric molecule.
Recovering said chimeric molecule from said culture.
Detailed methods of producing the individual components and the chimeric molecule are provided below.
The chimeric molecule may be administered in vivo or ex vivo.
The product is then cloned into an expression vector for production of the chimeric molecule.
Immobilized chimeric molecule is detected by detecting the immobilized detectable label.
DNA polymerase generally can not process across the part of a chimeric molecule containing the unnatural linkage.
The chimeric molecule will then act as a highly specific bifunctional linker.
The targeting component of the chimeric molecule can be against a cell surface marker.
Thus, if analyte is present, less of the antibody binds to the chimeric molecule.
The resultant chimeric molecule is then screened or selected for retention of activity.
T-lymphocyte directly with the chimeric molecule.
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The activation of a chimeric molecule can also be regulated by a BM.
In some embodiments, the targeting moiety of the chimeric molecule is an antibody.
The chimeric molecule of may comprise a PE as defined above.
In an embodiment of the disclosure, the chimeric molecule comprises a linker.
A chimeric molecule comprising the antibody of claim 27 fused to a heterologous amino acid sequence.
In an embodiment of the invention, the chimeric molecule comprises a linker.
When the chimeric molecule is combined with an appropriate binding molecule, its activity is modulated.
As such, assay systems employing the chimeric molecule is also contemplated.
The single, chimeric molecule has the desired functionality of all of its constituent molecules.
In an alternative, the targeting moiety of the chimeric molecule may be a cytokine.
In a non-limiting embodiment, a chimeric molecule may be prepared by assemblying a reassortment of partial molecular sequences.
More preferably, there is provided a human cell line transiently transfected with the chimeric molecule.
In another embodiment, the chimeric molecule is synthesized as a single contiguous polypeptide.
Alternatively, the double stranded segment of the chimeric molecule is RNA.
In a non-limiting embodiment, a chimeric molecule may be prepared by assembling a reassortment of partial molecular sequences.
APCs are sensitized by contacting / incubating them with the chimeric molecule.
These methods involve providing a chimeric molecule comprising an effector molecule, that is a detectable label.
Chimeric molecule comprising,.
A pharmaceutical composition of claim 7, wherein the chimeric molecule is a single chain fusión protein.
The chimeric molecule of claim 47 wherein said heterologous amino acid sequence comprises an immunoglobulin sequence.
Accordingly, in some embodiments, the chimeric molecule is an immunotoxin.
The chimeric molecule may comprise an Apo-2 polypeptide fused to an immunoglobulin sequence.
An example of a suitable immunizing agent is an Apo-2-IgG fusión protein or chimeric molecule.
Such a chimeric molecule can comprise multiples of the same subsequence of STEAP-1.
This affinity chromatography step can result in an chimeric molecule preparation that is > 95 % pure.
An example of such a chimeric molecule comprises the Apo-2 ligand fused to a tag polypeptide sequence.
In certain embodiments, a RANKL antibody-PTH / PTHrP chimeric molecule is administered alone.
In certain embodiments, a chimeric molecule comprises four PTH / PTHrP peptides per one RANKL antibody.
A polynucleotide encoding a RANKL antibody-PTH / PTHrP chimeric molecule of any of 1 to 53.
The activated chimeric molecule is referred to as APC-PT Gla.
A pharmaceutical composition comprising a RANKL antibody-PTH / PTHrP chimeric molecule of any of 1 to 53.
The chimeric molecule of claim 4, wherein X is a MAGE epitope derived from melanoma cells.
In certain embodiments, a RANKL antibody-PTH / PTHrP chimeric molecule is for administration alone.
A chimeric molecule according to claim 7 wherein said HIV RNA is the REV pre-mRNA.
A method of producing a RANKL antibody-PTH / PTHrP chimeric molecule comprising culturing the host cell of 56.
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