Examples of 'chimeric oligonucleotides' in a sentence
Meaning of "chimeric oligonucleotides"
Chimeric oligonucleotides: These are artificial DNA or RNA sequences composed of elements from different sources. They are often used in molecular biology and genetic engineering research to study gene function and expression
How to use "chimeric oligonucleotides" in a sentence
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chimeric oligonucleotides
Chimeric oligonucleotides can be of several different types.
These oligonucleotides are designated inverted chimeric oligonucleotides.
Chimeric oligonucleotides are included in the preferred modifications of the invention.
Certain oligonucleotides of this disclosure are chimeric oligonucleotides.
Methods for preparing chimeric oligonucleotides are also known.
Certain preferred oligonucleotides described herein are chimeric oligonucleotides.
Chimeric oligonucleotides are included in the preferential modifications of the invention.
Certain oligonucleotides of this invention are chimeric oligonucleotides.
Inverted chimeric oligonucleotides were also generally less mitogenic than phosphorothioate oligonucleotides.
Certain preferred oligonucleotides of this disclosure arc chimeric oligonucleotides.
Included among such oligonucleotides are chimeric oligonucleotides having different types of modified internucleoside linkages.
The compositions of the invention may optionally be chimeric oligonucleotides.
Traditional chimeric oligonucleotides produce much less prolongation of aPTT than do traditional phosphorothioate oligonucleotides.
Also contemplated are the use of oligonucleotides which are chimeric oligonucleotides.
The term also includes chimeric oligonucleotides which contain two or more chemically distinct regions.
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The present invention also includes antisense oligonucleotides which are chimeric oligonucleotides.
Generally, inverted chimeric oligonucleotides retain this characteristic.
Oligonucleotides with regions of distinct backbone chemistries are also examples of chimeric oligonucleotides.
In certain embodiments, chimeric oligonucleotides are mixed-backbone antisense oligonucleotides.
Antisense compounds useful in the methods of the present disclosure include chimeric oligonucleotides.
Additional chimeric oligonucleotides with various 2 ' modifications were prepared and tested.
Particularly preferred antisense oligonucleotides utilized herein include chimeric oligonucleotides and hybrid oligonucleotides.
The 2 ' modified chimeric oligonucleotides discussed above are not active in uniform phosphodiester backbones.
In certain embodiments, oligomeric compounds are chimeric oligonucleotides.
In certain such embodiments, the chimeric oligonucleotides comprise differently modified nucleotides.
In certain instances of the disclosure, oligomeric compounds are chimeric oligonucleotides.
Chimeric oligonucleotides contain deoxyribonucleosides only, but have regions containing different internucleoside linkages.
Thirdly, carbohydrates on the liposomal membrane can be used for liver uptake of chimeric oligonucleotides.
In another embodiment, certain preferred chimeric oligonucleotides are those disclosed in the Examples herein.
The term " oligonucleotide " includes hybrid and chimeric oligonucleotides.
The present invention also provides chimeric oligonucleotides targeted to nucleic acids encoding human STAT3.
Comparative Figure 2 shows mixed backbone, chimeric and inverted chimeric oligonucleotides used in the current studies.
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With chimeric research involving human cells
The antibodies may be chimeric or of a single species
Chimeric gene for the transformation of plants
Examples of using Oligonucleotides
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Longer oligonucleotides lead to increased transformation efficiency
Corresponding synthetic miRNA oligonucleotides were used as standards
Two oligonucleotides are constructed from this sequence
