Examples of 'clostridial toxin' in a sentence
Meaning of "clostridial toxin"
clostridial toxin: A poisonous substance produced by certain bacteria of the Clostridium genus. It is often associated with foodborne illnesses or infections
How to use "clostridial toxin" in a sentence
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clostridial toxin
Processes for obtaining a clostridial toxin.
The clostridial toxin is preferably botulinum toxin or tetanus toxin.
Fluorescence polarization assays for determining clostridial toxin activity.
The amount of clostridial toxin substrate can be varied in a method of the invention.
The stabilizing effect is achieved by bringing a clostridial toxin in contact with the polysaccharide.
A variety of Clostridial toxin recognition sequences are discussed herein below.
The first domain optionally comprises a fragment or variant of a clostridial toxin light chain.
A variety of Clostridial toxin substrates are discussed herein below.
These cleavage sites can be incorporated within the same or different clostridial toxin recognition sequences.
A wide variety of Clostridial toxin recognition sequence are useful in aspects of the invention.
The cell compositions disclosed in the present specification are capable of Clostridial toxin intoxication.
A wide variety of Clostridial toxin recognition sequences are useful in aspects of the invention.
There are several useful ways by which the Clostridial toxin may be locally administered.
The effect of a Clostridial toxin can be determined by determining a potency of the toxin.
The use of any of the preceding Claims wherein said clostridial toxin comprises BoNT.
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The exogenous Clostridial toxin substrate can be transiently or stably contained in the cell.
The present invention relates to a medicament for determining an effect of a Clostridial toxin upon a muscle.
These steps can include obtaining a purified Clostridial toxin and then compounding the purified Clostridial toxin.
A Clostridial toxin disclosed herein also includes a Clostridial toxin complex.
In other embodiments, the clostridial toxin is TeNT.
According to a preferential method of the invention, the cholinergic neurotoxin is a clostridial toxin.
Preferably, the clostridial toxin is a botulinum toxin.
As noted, the polysaccharide exhibits a stabilizing effect on the clostridial toxin.
Non-protein clostridial toxin compositions.
Cross-linker moieties also can be useful for preparing a clostridial toxin substrate.
Non-protein stabilized clostridial toxin pharmaceutical compositions.
Clostridial toxin substrates disclosed in the present specification include, in part, a fluorescent member.
A method of the invention relies on a clostridial toxin substrate which includes, in part, a fluorophore.
Clostridial toxin substrates disclosed in the present specification include, in part, a fluorophore binding protein.
Protein contaminants present in the composition binding and thus co-eluting with the clostridial toxin.
In some embodiments, the clostridial toxin pharmaceutical composition comprises a poloxamer.
Column chromatography to purify ( fractionate ) a Clostridial toxin is well known.
In some emobdiments, the clostridial toxin pharmaceutical composition comprises a polysorbate.
In further aspects of this embodiment, an endogenous Clostridial toxin receptor is, e.
In an embodiment, a Clostridial toxin pharmaceutical composition comprises a sugar.
In another embodiment, a cell stably contains a membrane-associated Clostridial toxin substrate.
Administering the Clostridial toxin to a muscle ;.
The cell of item 1, wherein the receptor is an endogenous Clostridial toxin receptor.
In some embodiments, the Clostridial toxin pharmaceutical composition comprises trehalose.
The cell of item 1, wherein the receptor is an exogenous Clostridial toxin receptor.
In an embodiment, a Clostridial toxin active ingredient pharmaceutical composition comprises a sugar.
The use according to claim 1 wherein the Clostridial toxin is a botulinum toxin.
A Clostridial toxin can also be made by known recombinant means by a non-Clostridial bacterium.
Thus, in an embodiment, a cell capable of Clostridial toxin intoxication can be a neuron.
In one embodiment, Clostridial toxin activity from a sample is determined by detecting the fluorescence intensity.
FIG . 1 shows a schematic of the current paradigm of Clostridial toxin posttranslational processing.
Thus in an embodiment, a Clostridial toxin active ingredient pharmaceutical composition comprises a surfactant.
In another embodiment, a cell transiently contains an membrane-associated Clostridial toxin substrate.
In an embodiment, the present Clostridial toxin pharmaceutical composition comprises a disaccharide.
The composition of 1, wherein said cell transientiy contains said Clostridial toxin substrate.
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