Examples of 'constant domain' in a sentence
Meaning of "constant domain"
Constant domain: In various contexts like biology or computing, this term refers to a specific region or part that remains unchanged or consistent
How to use "constant domain" in a sentence
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constant domain
The antibody also comprises a constant domain.
Heavy chain constant domain regions appear in red.
Each antibody has a different heavy chain constant domain.
Fd variable and first constant domain of a heavy chain.
The constant domain has a sequence intrinsic to each animal species.
A light chain comprises a constant domain and a variable domain.
Also described herein are isolated polypeptides comprising an immunoglobulin constant domain.
Light chain constant domain regions appear in amber.
An immunoglobulin chain comprises a variable domain and optionally a constant domain.
An immunoglobulin constant domain refers to a heavy or light chain constant domain.
Each chain is in turn comprised of a variable domain and a constant domain.
The light chain constant domain may be a kappa or lambda constant domain.
Each heavy and light chain may comprise a variable and a constant domain.
The constant domain of the antibody heavy chain may be selected accordingly.
They refer to the second and third constant domain of antibody heavy chains.
See also
The constant domain of such antibodies can be omitted while retaining antigen binding activity.
A light chain also consists of one constant domain and one variable domain.
Such variable domain sequences may then be combined with a desired human constant domain.
The heavy chain constant domain is preferably an IgG class constant domain.
The alpha chain is shorter than the beta chain due to a smaller constant domain.
The extracellular constant domain has a membrane proximal region and an immunoglobulin region.
The antibody of the invention further comprises a human constant domain of the IgG isotype.
The light chain constant domain may be of either the kappa or lambda type.
This fragment was inserted into the similarly digested vector containing the lambda constant domain.
The immunoglobulin constant domain sequence can be an immunoglobulin heavy chain constant domain sequence.
A binding protein of the present disclosure may alternatively comprise a heavy chain feline immunoglobulin constant domain.
Antibodies also include chimeric antibodies having variable and constant domain regions derived from different species.
TNFR and a constant domain of an immunoglobulin.
Each light chain comprises a light chain variable domain VL and a light chain constant domain CL.
Substitute constant domain portions can be obtained from compatible recombinant DNA sequences.
Lambda variable domains fused to a Kappa constant domain and a Lambda constant domain.
In a preferred embodiment, the polypeptide is an immunoglobulin constant domain.
The N terminal constant domain is underlined.
In contrast, the remaining domains constitute a constant domain.
The C terminal constant domain is underlined.
In one embodiment, the immunoglobulin sequence is an immunoglobulin constant domain.
Optionally the constant domain is an IgG domain e . g.
Both a and B chains of the T cell receptor consist of a constant domain and a variable domain.
Preferably, the constant domain sequence is human in origin.
In some embodiments, the heterologous polypeptide is an immunoglobulin constant domain.
Particularly preferred is the IgG4 constant domain comprising this change.
Cy is a constant domain from a light or heavy chain, in particular a light chain.
A full-length antibody includes a constant domain and a variable domain.
The constant domain of an antibody according to the invention is of the IgG1 type.
Alternatively, the polypeptide may be the human IgM constant domain.
In other embodiments, the constant domain lack one or more effector functions.
The polypeptide of claim 19 further comprising an immunoglobulin constant domain sequence.
Optionally, the constant domain of an immunoglobulin light chain can be of the λ type.
The immunoglobulin sequence typically, but not necessarily, is an immunoglobulin constant domain.
In some embodiments, the immunoglobulin constant domain is a heavy chain constant domain.
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