Examples of 'constant domains' in a sentence
Meaning of "constant domains"
constant domains: Constant domains refer to specific regions of a protein that remain unchanged or consistent in structure. They play a critical role in the overall functions and characteristics of the protein
How to use "constant domains" in a sentence
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constant domains
The sequence of the constant domains is irrelevant.
The constant domains of such antibodies are preferably human.
These polynucleotides also encode constant domains.
Pairing of the constant domains results in formation of the minibody.
The underlined portions are the constant domains.
Analogues of human constant domains may alternatively be advantageously used.
The tandem diabodies are devoid of immunoglobulin constant domains.
Other combinations of IgG constant domains are also discussed.
Constant domains are also called part of the framework region.
The underlined portions depict the constant domains.
The constant domains are not involved directly in binding an antibody to an antigen.
Antibodies comprising chimeric constant domains.
The constant domains useful in the invention provide complement binding.
Each chain comprises both variable and constant domains.
Human native sequence constant domains or amino acid sequence variant thereof.
See also
These units contain variable domains and constant domains.
The constant domains of a chimeric antibody are usually derived from a human antibody or antibodies.
Some molecules can include one or more constant domains or a portion thereof.
The remaining constant domains of the heavy chains are aligned with each other.
Engineered cysteines are preferably introduced into the constant domains of heavy or light chains.
The constant domains of the antibody molecule are derived from those of a human antibody.
The variable domain frameworks and constant domains were derived from human antibody sequences.
Both polypeptide chains have a molecular architecture formed by antibody variable and constant domains.
Antibodies of different isotypes have different constant domains and therefore have different effector functions.
Each heavy chain has at one end a variable domain followed by a number of constant domains.
The Fc constant domains can be from any mammalian or avian species.
This classification and nomenclature is based on the amino acid sequences of their constant domains.
The constant domains of the Fc region interact with cells of the immune system.
The heavy and light chains are both divided into variable domains and constant domains.
C refers to constant domains and V refers to variable loops.
There are four amino acid changes between these B constant domains.
Different constant domains may be appended to the humanized VI and VH regions provided herein.
Antibodies of the invention may have both Variable and Constant domains.
The constant domains are those of a human IgG1.
ADCC and optionally CDC are provided by the combination of variable and constant domains.
The constant domains may be native sequence constant domains e . g.
In some embodiments, the constant domains have effector function.
The constant domains can be native sequence constant domains e . g.
In an embodiment, a humanized antibody has constant domains of human origin.
Thus, where constant domains are present these are preferably human constant domains.
In one embodiment, analogues of human constant domains may be used.
One or more constant domains derived from an IgE, preferably a human IgE.
Preferably the framework regions and / or constant domains are human.
Preferably all constant domains ( both light and heavy ) are human constant domains.
In addition, combinations of two or more different constant domains may be used.
In other embodiments, the constant domains are chimeric domains comprising portions of different immunoglobulin molecules.
Antibodies are known to have variable regions, a hinge region, and constant domains.
In some aspects, one or more constant domains can be partially or entirely deleted.
In yet other embodiments, the consensus sequence is derived from human constant domains.
Exemplary heavy chain IgG1 constant domains according to the invention are depicted in Figure 5A.
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