Examples of 'costimulatory molecules' in a sentence
Meaning of "costimulatory molecules"
costimulatory molecules: Proteins on the surface of cells that regulate the immune response by providing signals that activate or inhibit immune cells
How to use "costimulatory molecules" in a sentence
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costimulatory molecules
The interaction properties of costimulatory molecules revisited.
Costimulatory molecules thus gain attention as potential therapeutic targets.
No significant expression of positive costimulatory molecules was detected.
Modulation of costimulatory molecules and their receptors permits the modulation of various immune functions.
The extracellular portion of such costimulatory molecules can also be used.
Genomic structure of recombinant fowlpox viruses expressing murine or human costimulatory molecules.
The effect of the triad of costimulatory molecules on DCs was completely unexpected.
The vector vaccine comprises foreign nucleic acid sequences encoding three costimulatory molecules.
The second signal is transmitted by costimulatory molecules on the surface of the dendritic cell.
The present invention provides plasmid vectors comprising a foreign nucleic acid sequence encoding three costimulatory molecules.
Inhibitory receptors that bind to costimulatory molecules have also been identified on immune cells.
These include inter alia its property of reducing the expression of costimulatory molecules on DC.
The foreign genes encoding the costimulatory molecules may be obtained from a variety of sources.
Adjuvants also include biological molecules, such as costimulatory molecules.
Represents a family of costimulatory molecules which are members of the Ig gene superfamily.
See also
Also as described herein, the DCs express costimulatory molecules.
Newer approaches incorporating costimulatory molecules that enhance Tcell activation are also being investigated.
In all experiments, CpG was superior to GMCSF in enhancing expression of costimulatory molecules.
Adjuvants can be administered in conjunction with costimulatory molecules to additionally augment the immune response.
DCs cultured with live or apoptotic antigen donor cells, expressed equivalent levels of costimulatory molecules.
At present, two major families of costimulatory molecules have been identified.
T cell costimulatory molecules contribute to the activation of antigen-specific T cells.
These previous studies were carried out using two costimulatory molecules and retroviral vectors.
Furthermore, ligation of costimulatory molecules provides a survival signal essential for T cells to prevent apoptosis.
Many of the B7 superfamily members were initially characterized as T cell costimulatory molecules.
Activated DCs display upregulated costimulatory molecules and secrete CTL-promoting cytokines.
Costimulatory molecules are confined to professional antigen-presenting cells ( APCs ).
Percentage of inhibition of LPS-induced expression of costimulatory molecules in differentially treated DCs.
It is proposed that apoEp1 . B immunization stimulates DC differentiation with an increase in B7 costimulatory molecules.
Effect of multiple costimulatory molecules on T-cell proliferation.
Successful protection using muB7.1 led to studies evaluating combinations of costimulatory molecules.
As a result, both these studies conclude that other costimulatory molecules must be supporting T-cell function.
Genomic structure of recombinant vaccinia virus vT238 expressing CEA ( 6D ) and three human costimulatory molecules.
TH2 cytokines downregulate costimulatory molecules and inhibit the maturation and function of antigen-presenting dendritic cells.
The B7-DC gene is a member of the B7 family of genes encoding costimulatory molecules.
Signal 2 is provided by costimulatory molecules expressed by professional antigen-presenting cells ( APC ).
Regulation of T cell immunity by the CD28 family of costimulatory molecules.
Specifically, DCs upregulate costimulatory molecules and produce cytokines such as IL-12 upon activation.
Adjuvants include biological molecules ( a " biological adjuvant " ), such as costimulatory molecules.
The second signal is delivered to T cells by costimulatory molecules expressed on antigen-presenting cells ( APCs ).
Anti - costimulatory molecules such as Abatacept, Belimumab ;.
Freshly isolated IPCs are negative for costimulatory molecules CD80 and CD86.
However, these cells did not express as much of the CD40 and CD86 costimulatory molecules.
Each monomeric polypeptide contains a high affinity binding site for the costimulatory molecules B7-1 and B7-2.
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