Examples of 'cyclin-dependent' in a sentence
Meaning of "cyclin-dependent"
cyclin-dependent (adjective): Describing proteins or enzymes that require the presence of cyclin molecules to become activated or function properly, commonly associated with cell cycle regulation in biology
How to use "cyclin-dependent" in a sentence
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cyclin-dependent
These compounds inhibit cyclin-dependent kinases.
Cyclin-dependent kinase inhibitor proteins.
This enzyme is a member of cyclin-dependent kinase protein family.
Cyclin-dependent kinase inhibitors may prove useful in treating cancer.
The compounds are described to be potent inhibitors of cyclin-dependent kinases 4.
Cdk5 is a homologue of cyclin-dependent kinases and rather ubiquitously expressed.
The selectivity is thus clearly superior with respect to cyclin-dependent kinases.
All key positions of cyclin-dependent kinases are conserved in this protein.
The invention also concerns a peptide capable of binding to a cyclin-dependent kinase.
A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase.
One suitable family of protein kinases are the cyclin-dependent protein kinases.
The cyclin-dependent kinase catalytic units are activated by regulatory subunits known as cyclins.
The present invention provides novel small molecule inhibitors of cyclin-dependent kinases.
The discovery that inhibition of a cyclin-dependent kinase is involved in mediating a hypoalgesic effect was unexpected.
Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases CDKs.
See also
Hydroxyethyl sulfonate of cyclin-dependent protein kinase inhibitor, crystalline form thereof and preparation method therefor.
Each step in the cell cycle is regulated by a distinct and specific cyclin-dependent kinase.
The inhibitor may also inhibit more than one cyclin-dependent kinase selected from the above-recited group.
They also lead to the search, by screening for molecules which inhibit cyclin-dependent kinases.
Effect of flavopiridol on cyclin-dependent kinase activity in HASMC.
These pyridotriazine and pyridopyridazine analogs are inhibitors of tyrosine kinases and cyclin-dependent kinases ( cdks ).
Regulatory phosphorylation sites of cyclin-dependent kinases are described inter alia in Shuttleworth, Progr.
Specifically, kinase inhibitors also include monoclonal or polyclonal antibodies directed against cyclin-dependent kinases.
In a specific embodiment the cyclin-dependent kinase is a Group I CMCG kinase.
Cyclin-dependent kinase activators ( CAKs ) have a positive regulatory action on CDKs.
Cyclins function as regulators of CDKs Cyclin-dependent kinase.
Cdk see cyclin-dependent kinase.
The compounds of Formula I are inhibitors of cyclin-dependent kinases.
S and cyclin-dependent kinase.
More particularly, the invention relates to cyclin-dependent protein kinases.
Cyclin-dependent kinases ( CDKs ) are enzymes which are critical to cell cycle control.
Activators of cyclin-dependent kinases.
In other embodiments, for example, an inducer of cell immortality is a cyclin-dependent kinase.
The role of cyclin-dependent kinases ( " cdks " ) in the regulation of cellular proliferation is well established.
Abemaciclib blocks the effects of proteins called cyclin-dependent kinase 4 and 6.
Cyclin-dependent kinases ( CDKs ) are a family of serine / threonine protein kinases playing important cellular functions.
The compounds of the invention are inhibitors of cyclin-dependent kinase enzymes ( CDKs ).
Specific cyclin-dependent kinase complex ( cyclin-CDK ) combinations determine the specific downstream proteins targeted.
In one embodiment the one or more protein kinase ( s ) is a cyclin-dependent protein kinase.
The cyclin-dependent kinases ( CDKs ) are serine-threonine protein kinase that regulates mammalian cell division.
They are selective against p38 kinase relative to cyclin-dependent kinases and tyrosine kinases.
Cyclin-dependent kinases (CDKs) are serine-threonine kinases which regulate progression through the eukaryotic cell cycle.
One of the ppar ¿ modulation mechanisms is through the phosphorylation by the cyclin-dependent kinase 5 cdk5.
Palbociclib works by blocking proteins called cyclin-dependent kinase 4 and 6, which regulate cell growth and division.
Cyclin-dependent kinase activating kinase ( CAK ) is a positive regulator of CDKs.
Cell cycle progression is mainly regulated by cyclins, cyclin-dependent kinases ( cdk ) and cdk inhibitors cdkis.
Furthermore, Cyclin-dependent kinases ( CDK ) were also shown as regulator of this phosphorylation site.
They are also surprisingly selective against p38 kinase relative to cyclin-dependent kinases and tyrosine kinases.
A molecule called cyclin-dependent kinase ( CDK ) regulates the cell cycle.
The cell cycle progression is controlled by the activity of cyclin-dependent kinases (CDK).
