Examples of 'dihydrofolate reductase' in a sentence
Meaning of "dihydrofolate reductase"
Dihydrofolate reductase (DHFR) is an enzyme involved in the folate metabolism pathway. It plays a crucial role in the synthesis of DNA and RNA by catalyzing the conversion of dihydrofolate to tetrahydrofolate. DHFR is targeted by certain antibiotics and antimetabolite drugs for their therapeutic effects in treating bacterial infections and cancer
How to use "dihydrofolate reductase" in a sentence
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dihydrofolate reductase
Dihydrofolate reductase inhibitors are one type of antifolates.
It is an antifolate and acts as an inhibitor of dihydrofolate reductase.
It is a dihydrofolate reductase inhibitor.
Leukemia cells are dependent on the enzyme dihydrofolate reductase.
Dihydrofolate reductase inhibitors.
Aditoprim is an antibacterial dihydrofolate reductase inhibitor.
Dihydrofolate reductase marker genes permit selection with methotrexate in a variety of hosts.
This inhibits the malarial dihydrofolate reductase enzyme.
Dihydrofolate reductase or ampicillin resistance gene may be used as a selection marker gene.
Lamotrigine is a weak inhibitor of dihydrofolate reductase.
Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis.
Tetrahydrofolic acid is produced from dihydrofolic acid by dihydrofolate reductase.
Mutations in the malarial gene for dihydrofolate reductase may reduce its effectiveness.
The compounds appear to be particularly active as inhibitors of dihydrofolate reductase.
The inhibition of the dihydrofolate reductase keeps the folic acid in an inactive state.
See also
These principles are applied to the inhibition of dihydrofolate reductase by methotrexate.
The dihydrofolate reductase gene from Mus musculus as a selectable marker in eukaryotic cells.
These cells are deficient in the dihydrofolate reductase gene.
Human dihydrofolate reductase ( hDHFR ) is an enzyme that is essential to cell proliferation.
Potent inhibitor of dihydrofolate reductase.
It was expected to work by blocking the action of a bacterial protein called dihydrofolate reductase.
Methotrexate blocks the action of dihydrofolate reductase and thereby halts the production of nucleotides.
Preferable in the present disclosure may be a cell deficient in dihydrofolate reductase.
Preferably the second nucleotide sequence encodes a dihydrofolate reductase polypeptide and the selection agent is methotrexate.
The proguanil component of malarone acts by inhibiting the parasitic dihydrofolate reductase.
These expression vectors also contain the dihydrofolate reductase gene for selecting stable CHO transfectants.
Antifolate agents work by inhibiting the action of key enzymes thymidylate synthase and dihydrofolate reductase.
Such markers include methotrexate, dihydrofolate reductase or neomycin resistance.
A preferred embodiment of the present invention focuses on a PCA based on the enzyme dihydrofolate reductase.
Inhibition of dihydrofolate reductase in the malaria parasite disrupts deoxythymidylate synthesis . ”.
Methotrexate is an inhibitor of dihydrofolate reductase.
Coli, dihydrofolate reductase and neomycin resistance genes in eukaryotic expression systems.
A frequently used mammalian marker is the dihydrofolate reductase gene.
Dihydrofolate reductase is inhibited by methotrexate which prevents binding of its substrate, folic acid.
These compounds belong to the class of dihydrofolate reductase inhibitors.
Dihydrofolate reductase produced using the coupled in vitro transcription / translation reactions is active.
Individual colonies were selected based upon expression of the dihydrofolate reductase gene from the vector.
In the folate metabolism, the dihydrofolate reductase ( dhfr ) catalyses the reduction of dihydrofolate to tetrahydrofolate.
The vector preferably includes a suitable marker such as a gene for dihydrofolate reductase or glutamine synthetase.
They inhibit bacterial dihydrofolate reductase and potentiate the antibacterial activity of sulphonamides such as e . g.
The majority of antifolates work by inhibiting dihydrofolate reductase DHFR.
Transforming a dihydrofolate reductase gene-deficient host cell with the expression vector ; and.
The Tp resistance gene encodes a type II dihydrofolate reductase.
The coding region of the dihydrofolate reductase gene, folA, was replaced with a kanamycin resistance determinant.
A stereospecific reduction of dihydrofolate catalyzed by dihydrofolate reductase has been reported I.
DHFR * is a mutant dihydrofolate reductase gene that demonstrates a reduced affinity for methotrexate.
To do this, it needs a specific enzyme called dihydrofolate reductase.
The enzymes ribonucleotide reductase, dihydrofolate reductase and thymidine synthetase are typical targets.
Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase.
The lentivector of claim 1, wherein the dihydrofolate reductase is a human dihydrofolate reductase.
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Dihydrofolate reductase inhibitors are one type of antifolates
Trimethoprim is a potent inhibitor of bacterial dihydrofolate reductases
It is a dihydrofolate reductase inhibitor
