Examples of 'dihydrofolate' in a sentence
Meaning of "dihydrofolate"
dihydrofolate (noun) - 'Dihydrofolate' refers to a chemical compound that is important for processes like DNA synthesis and cell growth. It is commonly associated with the drug methotrexate, which inhibits the action of dihydrofolate reductase
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- Any salt or ester of dihydrofolic acid
How to use "dihydrofolate" in a sentence
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dihydrofolate
Dihydrofolate reductase inhibitors are one type of antifolates.
Trimethoprim is a potent inhibitor of bacterial dihydrofolate reductases.
It is a dihydrofolate reductase inhibitor.
It is an antifolate and acts as an inhibitor of dihydrofolate reductase.
Dihydrofolate reductase inhibitors.
Aditoprim is an antibacterial dihydrofolate reductase inhibitor.
Dihydrofolate reductase marker genes permit selection with methotrexate in a variety of hosts.
This inhibits the malarial dihydrofolate reductase enzyme.
Dihydrofolate reductase or ampicillin resistance gene may be used as a selection marker gene.
Leukemia cells are dependent on the enzyme dihydrofolate reductase.
Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis.
Lamotrigine is a weak inhibitor of dihydrofolate reductase.
The inhibition of the dihydrofolate reductase keeps the folic acid in an inactive state.
Tetrahydrofolic acid is produced from dihydrofolic acid by dihydrofolate reductase.
Mutations in the malarial gene for dihydrofolate reductase may reduce its effectiveness.
See also
Reactions were initiated by adding dihydrofolate.
Methotrexate blocks the action of dihydrofolate reductase and thereby halts the production of nucleotides.
The compounds appear to be particularly active as inhibitors of dihydrofolate reductase.
Preferably the second nucleotide sequence encodes a dihydrofolate reductase polypeptide and the selection agent is methotrexate.
Preferable in the present disclosure may be a cell deficient in dihydrofolate reductase.
DHFR catalyses the conversion of dihydrofolate to the active tetrahydrofolate.
It was expected to work by blocking the action of a bacterial protein called dihydrofolate reductase.
Potent inhibitor of dihydrofolate reductase.
Antifolate agents work by inhibiting the action of key enzymes thymidylate synthase and dihydrofolate reductase.
The dihydrofolate reductase gene from Mus musculus as a selectable marker in eukaryotic cells.
These cells are deficient in the dihydrofolate reductase gene.
Assays were performed in the presence of saturating concentrations of NADPH and initiated with dihydrofolate.
These principles are applied to the inhibition of dihydrofolate reductase by methotrexate.
Dihydrofolate reductase, an enzyme that produces a compound required.
Methotrexate is an inhibitor of dihydrofolate reductase.
Human dihydrofolate reductase ( hDHFR ) is an enzyme that is essential to cell proliferation.
A frequently used mammalian marker is the dihydrofolate reductase gene.
A stereospecific reduction of dihydrofolate catalyzed by dihydrofolate reductase has been reported I.
The proguanil component of malarone acts by inhibiting the parasitic dihydrofolate reductase.
These expression vectors also contain the dihydrofolate reductase gene for selecting stable CHO transfectants.
A preferred embodiment of the present invention focuses on a PCA based on the enzyme dihydrofolate reductase.
Such markers include methotrexate, dihydrofolate reductase or neomycin resistance.
The ligands used were the inhibitor Methotrexate and the substrates dihydrofolate and NADPH.
Inhibition of dihydrofolate reductase in the malaria parasite disrupts deoxythymidylate synthesis . ”.
These compounds belong to the class of dihydrofolate reductase inhibitors.
It reduces dihydrofolate to tetrahydrofolate, an important cofactor involved in purine and thymidylate biosynthesis.
Individual colonies were selected based upon expression of the dihydrofolate reductase gene from the vector.
Coli, dihydrofolate reductase and neomycin resistance genes in eukaryotic expression systems.
The vector preferably includes a suitable marker such as a gene for dihydrofolate reductase or glutamine synthetase.
Dihydrofolate reductase is inhibited by methotrexate which prevents binding of its substrate, folic acid.
The majority of antifolates work by inhibiting dihydrofolate reductase DHFR.
Dihydrofolate reductase produced using the coupled in vitro transcription / translation reactions is active.
DHFR as part of its molecular mechanism reduces dihydrofolate to tetrahydrofolate.
In the folate metabolism, the dihydrofolate reductase ( dhfr ) catalyses the reduction of dihydrofolate to tetrahydrofolate.
The Tp resistance gene encodes a type II dihydrofolate reductase.
