Examples of 'downregulation' in a sentence
Meaning of "downregulation"
Downregulation is a biological process in which the activity, production, or sensitivity of molecules, receptors, or genes in a cell is decreased. It plays a crucial role in regulating various physiological functions, including hormone signaling, gene expression, and cellular responses to stimuli
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- The suppression of a response to a stimulus
- The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
How to use "downregulation" in a sentence
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downregulation
Downregulation was blocked by the opioid antagonist naloxone.
Regulation is preferably the downregulation of a cellular component.
This downregulation has not been fully explained.
This phenomenon is called receptor downregulation.
Occupation and downregulation of carrier proteins.
Downregulation and upregulation in drug addiction.
Methods of assessing downregulation are described herein.
Downregulation of gene expression in plant pathogens.
This finding was attributed to the downregulation of TJs proteins.
The result is downregulation of the specific autoimmune response.
Another potential mechanism of action of therapeutic antibodies is receptor downregulation.
Downregulation refers to the decrease in the number of receptor sites.
Shading indicates downregulation in mshl.
Downregulation of gene expression by siRNA.
Alternatively or additionally downregulation may employ antisense nucleic acid or ribozymes.
See also
Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress.
Methods of testing for downregulation are well known to those in the art.
Internalization of tyrosine receptor kinases has been associated with downregulation of the receptors.
Upregulation and downregulation can also happen as a response to toxins or hormones.
Studies have shown that it plays a role in the downregulation of osteoclasts.
This probably reflects downregulation in proliferation capacity of the inactive MCSs.
The term inhibition is used to indicate a decrease or downregulation of expression or activity.
Tipifarnib also showed downregulation of some transcripts not affected by the statin.
The truncation of the receptor protein results in the inability of downregulation after stimulation.
Glutamine synthetase downregulation reduces astrocyte protection against glutamate excitotoxicity to neurons.
This is mediated by upregulation of the proteolysis and downregulation of protein synthesis in muscle.
Mutant adipocytes exhibit downregulation of insulin signaling that is associated with glucose and insulin tolerance.
Membrane proteins serving as receptors are sometimes tagged for downregulation by the attachment of ubiquitin.
Conclusion BiP induced the downregulation many genes activated in monocyes in the inflammatory response.
Schematic of indicator constructs used to measure Naf medicated downregulation.
The mechanism of action is associated with downregulation of estrogen receptor protein levels.
Downregulation of amphiregulin can be also achieved by RNA silencing.
The ultradian rhythm is important for the downregulation of a dominant hemisphere or lobe.
Downregulation of a target can be also achieved by RNA silencing.
The latter method is for example downregulation through a dominant negative approach.
Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages.
Serious alcohol addiction results in a downregulation of GABA neurotransmitter receptors.
Prophylactic downregulation may be useful to prevent the recruitment of dermal T or NK cells.
DNA methylation can result in long term downregulation of specific genes.
Moreover specific downregulation of the expression of genes is feasible through RNA interference.
Antisense molecules for downregulation of NMDAR.
Downregulation of expression of any one of the PKS genes may increase ARA production.
Reduction of ROS induction through iNOS downregulation can be monitored by using this method.
Downregulation and Upregulation.
This interaction leads to downregulation of T cell clone activation.
Downregulation is a relative decrease in expression and / or activity.
It additionally causes downregulation of the Wnt inhibitor Dickkopfl.
This phenomenon is known as ligand-induced desensitization or downregulation.
Pharmacological downregulation of serum retinol is a valid treatment strategy for dry AMD and STGD.
A " change in gene expression " refers to detection of upregulation or downregulation.
