Examples of 'endothelin' in a sentence
Meaning of "endothelin"
Endothelin is a type of peptide that has potent vasoconstrictive effects, playing a role in regulating blood flow, cell growth, and hormone production.
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- Any of several polypeptides consisting of 21 amino acid residues that are produced in various cells and tissues, that play a role in regulating vasomotor activity, cell proliferation, and the production of hormones, and that have been implicated in the development of vascular disease.
How to use "endothelin" in a sentence
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endothelin
Alternative endothelin receptor antagonists may be considered.
Those receptors differ in their affinity to endothelin.
Endothelin also stimulates plasma renin activity.
A method for identifying endothelin receptors is provided.
Endothelin has also been implicated in preclampsia of pregnancy.
Cancer treatment with endothelin receptor antagonists.
Endothelin is also mitogenic for mesangial cells.
Vasoconstrictors released by the endothelium include endothelin.
Endothelin is involved in many human disease states.
Other biological activities by endothelin are also observed.
An endothelin receptor is obtained by culturing this transformant.
The clinical impact of dual endothelin blockage is unknown.
Endothelin and its potential role in glaucoma.
Endotoxin has been shown to promote the release of endothelin.
A number of endothelin receptors are regulated by various factors.
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Compounds of the formula inhibit the activity of endothelin.
Endothelin also can have mitogenic properties.
Disclose pyrazole derivatives with endothelin antagonist activity.
Increased endothelin and decreased vasodilation has been documented.
The sulfonamides of the present invention are inhibitors of endothelin receptors.
Regulation of endothelin production is primarily at the level of transcription.
They thus inhibit the biological effects of endothelin in mammals.
Endothelin plasma levels are elevated in certain disease states.
Compounds that exhibit endothelin antagonistic activity have been identified.
Endothelin causes a significant worsening of the internal hyperplasiaJ.
These data support a role of endothelin in the phathogenesis of vascular restenosis.
Endothelin constricts blood vessels and raises blood pressure.
Methods for inhibiting binding of an endothelin peptide to an endothelin receptor are provided.
Endothelin exists in higher levels.
Both cell types produce endothelin and possess endothelin receptors.
Endothelin appears to produce a preferential effect in the renal vascular bed.
A number of compounds that exhibit endothelin antagonistic activity have been identified.
Endothelin is a potent vasoconstrictor.
The protein encoded by this gene is a member of the endothelin family.
Those exposed to endothelin were more compact with no processes.
No adverse effects are expected when a healthy patient is administered an endothelin antagonist.
Changes in endothelin induced tension are recorded.
Tracleer tablets belong to the class of medicines called endothelin receptor antagonists.
Use of an endothelin receptor antagonist as emergency contraceptive agent.
More than one of the aforementioned endothelin antagonists may be used.
Membranes as endothelin receptors were isolated from inner medulla of porcine kidney.
All of the compounds exemplified or described herein exhibited activity as endothelin antagonists.
These two subtypes of endothelin receptors are differently distributed in tissues.
The emergency contraceptive agents of the present invention are endothelin receptor antagonists.
It is an endothelin receptor antagonist.
Sensitization of tumor cells to radiation therapy through the administration of endothelin agonists.
Alterations of plasma endothelin levels have also been demonstrated in human diabetes.
The compunds of the present invention are valuable inhibitors of endothelin converting enzyme.
Endothelin is a potent contractor of isolated airway tissue including human bronchus.
There is uncertainty as to whether endothelin receptor antagonists reduce mortality in this population.
