Examples of 'factor xia' in a sentence
Meaning of "factor xia"
factor xia: Factor XIIa, also known as Hageman factor, is a clotting protein that plays a role in the coagulation cascade
How to use "factor xia" in a sentence
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factor xia
Factor XIa levels were measured by a fluorogenic method.
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors.
Factor XIa is a plasma serine protease involved in the regulation of blood coagulation.
Diamide macrocycles as factor XIa inhibitors.
Advantageous compounds desirably have good inhibitory and selectivity for factor XIa.
Coagulation factor XIa.
Factor XIa then activates factor IX to factor IXa in the presence of calcium.
Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases.
A similar procedure is used for factor XI or factor XIa.
Factor XI is activated to factor XIa by Factor XIIa.
Factor XIa activates factor IX to IXa.
This activity is directly related to the amount of Factor XIa in the sample.
Thus, inhibitors of factor XIa are expected to be anticoagulant and profibrinolytic.
Factor XII is activated to factor XIIa which activates factor XI to factor XIa.
Factor XIIa then activates factor XI to factor XIa in the coagulation cascade.
See also
Activator molecules include thrombin, factor XIIa and factor XIa.
In clinical studies, elevated factor XIa concentrations were associated with an increased event rate.
Medicinal products for the treatment of blood coagulation disorders containing thrombin-free factor XIa concentrate.
Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds.
FIX is inactive unless activated by Factor XIa or Factor VIIa.
A quantity of Factor XIa sufficient for a plurality of Factor IX assays ;.
In a specific embodiment, the amidolytic activity is Factor XIa activity present in the composition.
In one embodiment, the cleavage sequence ( s ) are cleavable by factor XIa.
Factor IX is activated by factor XIa and by factor VII / tissue factor complex.
Exemplary such sites include those recognized by thrombin, Factor XIa or Factor Xa.
Factor XIa in the presence of Ca2 + proteolytically activates factor IX to IXa.
In one instance, the cleavage sequence ( s ) are cleavable by factor XIa.
Measurements of Factor XIa ( FXIa ) levels ( fluorogenic method ).
One approach has been to target the inhibition of factor XIa ( FXIa ).
Table 1 below lists Factor XIa Ki values measured at 37 °C for the following Examples.
In another embodiment, the compounds of the present invention have Factor XIa Ki values ≤ 1 µM.
The ADAPTS13 activity on platelets can be enhanced by treatment with coagulation Factor XIa ( FXIa ).
The pharmaceutical composition according to ( 20 ), which is a factor XIa inhibitor.
Examples of suitable coagulation factors include thrombin, Factor VIIa, Factor Xa, or Factor XIa.
The pharmaceutical composition according to ( 20 ), for use as a factor XIa inhibitor.
Silica at a concentration of 0.5mg/ml is used to activate Factor XI to Factor XIa.
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