Examples of 'fcrn binding' in a sentence
Meaning of "fcrn binding"
fcrn binding - a term related to the Food Climate Research Network which focuses on the relationship between food and climate change
How to use "fcrn binding" in a sentence
Basic
Advanced
fcrn binding
The FcRn binding partner is conjugated with an antigen.
Mutations on both sides are necessary to completely inhibit FcRn binding.
Examples of FcRn binding variants of the present invention.
An immunoglobulin constant region or a portion thereof can be an FcRn binding partner.
The preferred FcRn binding partners are as described above.
Such conserved residues are singly mutated to alanine to determine their role in FcRn binding.
An FcRn binding partner is a portion of an immunoglobulin that binds to FcRn.
It also is preferred that the antigen be covalently coupled to the FcRn binding partner.
The relative FcRn binding of the variant compared to wild type are listed.
The invention involves the formation of a conjugate of an FcRn binding partner and an antigen.
Summary of FcRn binding properties of the Fc variants.
Certain of these mutations can confer new functionality upon the FcRn binding partner.
An FcRn binding partner is a portion of an Ig that binds to FcRn.
Suitable conjugate moieties include portions of immunoglobulin sequence that include the FcRn binding site.
Most preferably the FcRn binding partner is an Fc fragment of IgG.
See also
Certain of the above mutations may confer new functionality upon the FcRn binding partner.
Exemplary mutations and their effect on FcRn binding are listed in the following Table.
IgG antibody has longer plasma retention time as a result of FcRn binding.
FcRn binding data of Fc variants.
An Ig constant region or a portion thereof can be an FcRn binding partner.
It has been shown that FcRn binding capacity is intrinsic to domain-III of albumin.
Amino acid sequences of Visilizumab with various FcRn binding mutations.
That is, the pH dependency of FcRn binding affinity mimics the wild-type pH dependency.
Amino acid sequences of Daclizumab with various FcRn binding mutations.
Compositions may provide improved FcRn binding and / or serum half life relative to controls.
Amino acid sequences of Fontolizumab with various FcRn binding mutations.
FcRn binding affinity may be measured as follows,.
FcRn is capable of transporting immunogens as conjugates with FcRn binding partners.
Additionally, chimeric proteinscomprising an FcRn binding partner are endocytosed by cells expressing the FcRn.
The method of claim 1, wherein the portion of an immunoglobulin is an FcRn binding partner.
In one embodiment, an FcRn binding partner can be an Fc region.
Thus, it is an object of the present disclosure to provide new FcRn binding agents.
Competition FcRn binding data of wild-type Fc and Fc variants of the present invention.
The library was used for selections of FcRn binding Z variants.
The purity of the FcRn binding Z variants was analyzed by SDS-PAGE stained with Coomassie Blue.
In one embodiment, the second polypeptide is a polypeptide comprising an FcRn binding partner.
BIACORE analysis of human and mouse FcRn binding to wild - type and mutant Fc constructs.
In some embodiments, the human IgG constant region is modified to enhance FcRn binding.
The following Table 6 illustrates FcRn binding data . Values in parenthesis refer to standard deviation.
But one-sided asymmetric mutations are not sufficient to completely inhibit FcRn binding.
The identity of each purified FcRn binding Z variant was confirmed using LC / MS analysis.
In some embodiments, the targeting molecule comprises at least one functional FcRn binding site.
The displayed proteins retained FcRn binding capacity ( data not shown ).
In some embodiments, the Fc polypeptide is modified to enhance FcRn binding.
The method of claim 11, wherein the FcRn binding partner is an Fc or a fragment thereof.
The chimeric protein of E4, wherein the portion of an immunoglobulin is an FcRn binding partner.
The KD for FcRn binding for a representative parental antibody ( PaniX, anti-EGFR ) is also shown.
As described above, purified antibodies were tested for FcRn binding in competitive binding assays.
Table 6, FcRn binding characterisation of the Fc variants using ELISA and Surface Plasmon Resonance ( SPR ).
This variant places the insertion, an Asn, in the middle of an FcRn binding loop.
You'll also be interested in:
Examples of using Binding
Show more
Compliance with legally binding regional protocols
Legally binding provisions on availability of unleaded fuel
Adopt rigorous and binding reporting rules
Examples of using Fcrn
Show more
Soluble human FcRn was expressed by the following procedure
Fc variants with altered binding to FcRn
The FcRn binding partner is conjugated with an antigen
