Examples of 'fcyriib' in a sentence
Meaning of "fcyriib"
Fcyriib (adjective): This term does not have a widely recognized definition in English. It may be an acronym, a code, or a specialized term in a particular field
How to use "fcyriib" in a sentence
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fcyriib
An example of such an inhibitory FcR is FcYRIIb.
The FcYRIIb binding was assessed by the procedure described below.
Preferably the agent prevents or reduces FcYRIIb signaling.
This image represents the FcYRIIb staining pattern in unstimulated cells.
The ligand may be a polypeptide which binds to FcYRIIb.
Preferably the FcYRIIB humanized antibodies bind the extracellular domain of native human FcYRIIB.
Other groups have investigated the role of FcYRIIb in lymphoma.
Animals that express the human FcYRIIb are immunized with human FcYRIIa or vice versa.
Preferably the second antibody molecule prevents or reduces FcYRIIb signaling.
The ratio of FcYR IIa to FcYRIIb may also become altered on the immune cell.
Increased binding to FcYRIIB.
Thus crosslinking of FcYRIIB dampens the activating response to FcYR ligation and inhibits cellular responsiveness.
In a particularly preferred embodiment of the invention the recombinant soluble FcR is a FcYRIIb receptor.
The previous set of experiments had demonstrated that FcYRIIb regulates the internalisation of rituximab.
Preferably the antibodies of the invention bind the extracellular domain of native human FcYRIIB.
See also
FcYRIIB expression may be upregulated using cytokines and particular growth conditions.
The antibodies are optimized to possess reduced affinity for the human inhibitory receptor FcYRIIb.
It stains only cells expressing FcYRIIb NOT the closely related FcYRIIa.
Preferably the antibodies disclosed herein bind the extracellular domain of native human FcYRIIB.
Activation of FcYRIIB resulting in ITIM phosphorylation results in inhibition of the activating signaling cascade.
Suitably the coengagement molecule includes an immunoglobulin that binds IgE and FcYRIIb with high affinity.
Coaggregation of FcYRIIB and BCR leads to inhibition of cell cycle progression and cellular survival.
Decrease binding of said Fc domain to FcYRIIB.
Geo MFI values for FcYRIIb expression of the sorted cells are listed on the right.
This is measured by phosphorylation of the ITIM region of the FcYRIIb.
FcYRIIB bears an ITIM motif in its cytoplasmic region.
An example of the ITIM class of inhibitory receptors is the FcY receptor FcYRIIB.
FcYRIIb is the broadly expressed FcYR.
The mutants were assayed using an ELISA assay for determining binding to FcYRIIIA and FcYRIIB.
FcYRIIb has two inhibitory activities.
Supernatants from hybridoma cultures are screened for immunoreactivity against FcYRIIA or FcYRIIB using ELISA assays.
FcYRIIB expression can also be enhanced by increased cell density Tridandapani et al.
DLBCL and the majority of FL displayed low FcYRIIb expression.
The expression of the FcYRIIb receptor is restricted to phagocytes and B cells.
AlphaScreen assay showing binding of select alemtuzumab Fc variants to human FcYRIIb.
FcYRIIb is virtually present on all leukocytes with exception of NK cells and T cells.
In other aspects, the FcYRII is isoform FcYRIIb.
The FcYRIIB depletion by magnetic beads was repeated 5 times.
Combinations of substitutions for enhancing affinity to FcYRIIb include,.
However, FcYRIIA and FcYRIIB exhibit very different activities.
In some disclosures, the heteromultimer binds selectively to FcYRIIb.
Alternatively, FcYRIIb expression levels can be measured by immunohistochemistry of tumor biopsies.
Preferably, said amino acid modifications improve affinity to FcyRIIb.
In another specific embodiment, the FcYR is FcYRIIB, preferably a soluble dimeric FcYRIIB.
In some disclosures, the heteromultimer binds selectively to FcYRIIa and FcYRIIb.
Expression patterns of FcYRI, FcYRIIIA, and FcYRIIB are affected by different growth conditions.
In some disclosures, the heteromultimer binds selectively to FcYRIIIa and FcYRIIb.
Human monocytes express FcyRI, FcYRIIA, FcYRIIB and only a subpopulation expresses FcYREIIA.
For example, the antibodies block the binding of aggregated IgGs to FcYRIIB.
As described below, the FcYRIIB mutation was bred into cross-bred mice of the invention.
