Examples of 'framework region' in a sentence
Meaning of "framework region"
framework region: a specific part of a structure or system that provides support or a base for the rest of it
How to use "framework region" in a sentence
Basic
Advanced
framework region
The rodent framework region is preferably rat.
Such substitutions are usually in the framework region.
The framework region is shown in gray.
Constant domains are also called part of the framework region.
Optionally the framework region can be modified by further mutations.
Antibodies of the present invention further comprise a human framework region.
The extent of the framework region and CDRs have been defined.
The major part of the domain sequence is the framework region.
A suitable light chain variable framework region was designed in a similar manner.
The framework region may be naturally occurring or consensus framework regions.
A suitable light chain variable framework region can be designed in a similar manner.
This single change from germline was therefore maintained in the antibody framework region.
Additional framework region modifications can be made within the human framework sequences.
In the heavy chain variable domain there is an unusual feature in the framework region.
Additional framework region modifications may be made within the human framework sequences.
See also
An acceptor antibody was selected based on the amino acid homology within the framework region.
The variable framework region of the initial antibody may be a light chain or a heavy chain.
The acceptor antibody is chosen based on the amino acid homology in the framework region.
The framework region ligated to the CDR having a good antigen binding site is selected.
The consensus sequences are used to generate a desirable synthetic framework region for the humanized antibody.
Therefore, framework region derives from human antibody.
An example of alteration is a mutation which may be in either a CDR or a framework region.
In preferred embodiments, the framework region is a human framework region.
Preferably the CDR regions are grafted into a human framework region.
In preferred embodiments, all of the framework region is human framework region.
The expression vector also comprises a nucleotide sequence encoding framework region 4.
A " consensus framework " refers to the framework region in the consensus immunoglobulin sequence.
A humanized VHH domain may contain one or more fully human framework region sequences.
A mutation may be made in a framework region or constant domain to increase the half-life.
In some embodiments, the mutations are present in a framework region.
However, the two mAbs differ in the framework region of their heavy chain variable domains.
For example, they can comprise a human antibody framework region.
A framework region may comprise one or more amino acid changes for the purposes of " germlining ".
Accordingly, murine residues in the human framework region may be substituted.
Additional candidates for substitution are non-germline residues occurring in an acceptor framework region.
A " consensus framework " of an immunoglobulin refers to a framework region in the consensus immunoglobulin sequence.
Other candidates for substitution are non-germline residues occurring in a framework region.
Firstly, seven different point mutations in the framework region of the light chain were introduced.
For example, somatic mutations are relatively infrequent in the amino-terminal portion of framework region.
In this case, the CDR prior to mutagenesis and framework region together are naturally occurring.
The parent antibody may have a murine framework, but preferably has a human framework region.
The VI domain FR4 may comprise a framework region of human germline gene segment JL2.
Accordingly, CDRs are variable region sequences interspersed within the framework region sequences.
Figure 2 shows framework region 4 for the heavy chains and the mouse library.
In some embodiments, the constant and variable framework region sequences are human.
Many human antibody framework region sequences are compiled in Kabat et al ., supra, for example.
In certain embodiments, at least one residue in the human variable framework region is substituted.
The framework region makes up about 85 % of the variable region.
Comprises non-human hypervariable region residues and human framework region residues ; or.
The preferred framework region for the light chain may be λ3-3H.
You'll also be interested in:
Examples of using Framework
Show more
The policy framework for water operators
Provide a supportive legal and regulatory framework
Solidarity as an alternative framework for collaborative action
Examples of using Region
Show more
The reports from the region were horrifying
The region is constructing buildings to house migrants
An example of such a region is the shelf boundary
