Examples of 'framework regions' in a sentence
Meaning of "framework regions"
framework regions - usually refers to specific areas or sections within a larger structure or plan that serve as guidelines or parameters for development or decision-making
How to use "framework regions" in a sentence
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framework regions
The framework regions have been precisely defined.
Plain type indicates the framework regions.
Framework regions are described in greater detail below.
The analysis was constrained to the framework regions.
These framework regions separate the CDRs.
Similar mutagenesis can be performed in the framework regions.
The framework regions of human antibodies are largely conserved.
No changes in the framework regions are made.
Framework regions are boldface and altered amino acids are underlined.
Alterations also may be made in the framework regions.
The intervening framework regions are indicated in small caps.
Alterations may be made in one or more framework regions.
The remaining framework regions are converted to human sequences.
Fully human monoclonal antibodies include human framework regions.
Framework regions are not underlined.
See also
The CDRs are held in close proximity by the framework regions.
Framework regions are similarly numbered.
These remaining regions are generally referred to as the framework regions.
Suitable framework regions are well known and described in the art.
In the present disclosure the differences are in the framework regions.
The extent of the framework regions and CDRs have been defined.
Includes variable light and variable heavy framework regions.
The variable framework regions may be of human origin or of rat origin.
Such an antibody comprises CDRs and framework regions of rat origin.
The framework regions serve to hold the CDRs in an appropriate orientation.
The remaining parts of the variable regions are referred to as framework regions.
Framework regions may comprise human germline gene segment sequences.
The amino acid alterations may be introduced in the framework regions.
Framework regions include variable light and variable heavy framework regions.
The framework region may be naturally occurring or consensus framework regions.
The framework regions can also differ significantly from antibody to antibody.
The stability of this molecule can be attributed mostly to its framework regions.
These framework regions are fairly specific to the species in which the antibody was produced.
Regions between CDRs in the variable domain of an immunoglobulin are known as framework regions.
Human framework regions can be chosen to maximize homology with the mouse sequence.
Those skilled in the art will be aware of a variety of human framework regions.
Methods for modifications of framework regions are known in the art and are contemplated herein.
In this manner a sequence that lacks the intervening framework regions is created.
The sequences of the framework regions of different light or heavy chains are relatively conserved.
Humanisation typically involves grafting CDRs identified thereby into human framework regions.
The framework regions of the variable regions are substituted by corresponding human framework regions.
Another reference describes rodent CDRs supported by recombinantly veneered rodent framework regions.
These are framework regions that are used in a variety of antibodies that bind tumor markers.
Do not make a distinction between homology within the framework regions and CDRs.
These framework regions are quite specific of the specie in which the antibody was produced.
Sites of interest for substitutional mutagenesis include the CDRs and the framework regions.
The framework regions serve to hold the CDRs in an appropriate orientation for antigen binding.
As such they comprise both the framework regions and the CDRs of the acceptor antibody.
The framework regions of the variable regions may be substituted by corresponding human framework regions.
A chimeric antibody may be made that comprises CDRs and framework regions from different antibodies.
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