Examples of 'framework residues' in a sentence
Meaning of "framework residues"
framework residues: remnants or leftover elements from a particular framework or structure
How to use "framework residues" in a sentence
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framework residues
There may be subsequent manipulation of framework residues.
All framework residues were retained as human.
Preferably at least four of these framework residues are substituted.
Framework residues defining the subtype.
Preferably at least three of these framework residues are substituted.
Framework residues in the light chain may also be changed.
The positional consensus sequences apply only to framework residues.
Variable domain framework residues have little or no direct contribution.
The next step involves selecting human antibodies to supply framework residues.
Variable region framework residues have little or no direct contribution.
Only in exceptional cases will it be necessary to change a larger number of framework residues.
In addition several framework residues are also the murine amino acid.
Mouse antibody variable domains also contain somatic mutations in framework residues See Sem.
It consists essentially of human framework residues and murine hypervariable residues.
Mouse framework residues replaced by human framework residues are indicated as sphere models.
See also
From about one to about five framework residues may be altered.
Potential framework residues that may have affected the binding were identified.
Substitutions made at CDR or framework residues are italicized.
No donor framework residues were retained in the engineered light chain variable region.
Graft gH1 contains no murine framework residues.
The choice of framework residues can be critical in retaining high binding affinity.
Double-underlined sequences are donor framework residues retained in the grafts.
The framework residues that need to be preserved are amenable to identification through computer modeling.
These residues are known as framework residues and tend to be highly conserved.
Such framework residues can therefore directly contribute to the formation of a particular antigen specificity.
Such repeat units comprise framework residues and interaction residues.
Those framework residues that significantly improved affinity were incorporated into the humanized antibody.
However, some positions of framework residues may also be randomized.
Other framework residues that are candidates for substitution are residues creating a potential glycosylation site.
In each case graft 1 represents a graft without murine framework residues.
None of these unusual mouse framework residues were retained the humanized antibodies.
Framework residues are those residues of antibody variable regions other than hypervariable or CDR residues.
Asterisks indicate preferred murine framework residues and are illustrated above the amino acid residue.
In still other embodiments, the antibody comprises one or more non-human framework residues.
The positions of the framework residues were specified to certain amino acids each.
Similarly, the invention provides for the backmutation of framework residues in the light chain.
Identifying mouse framework residues that can influence conformation and antigen binding.
For example, from about one to about five framework residues may be altered.
A list of framework residues that differ between the human and murine sequences was constructed manually.
One approach is to " backmutate " one or more framework residues to the corresponding germline sequence.
Conserved framework residues within members of a canonical class are referred to as " canonical " residues.
Random mutagenesis of CDR and / or framework residues is described by, Barbas et al.
Thus, Fv framework residues of the human immunoglobulin can be replaced by corresponding non-human residues.
Random mutagenesis of HVR and / or framework residues is described by, Barbas et al.
Framework residues located at the VL / VH interfaz.
Figure 2 depicts the framework residues targeted for randomization.
In some instances, corresponding non-human residues replace Fv framework residues of the human Ig.
In this molecule, several murine framework residues were incorporated into the human framework.
A humanized antibody according to claim 11, having all human kappa 1 consensus light chain framework residues.
For example, substitution of nonhuman framework residues in the human sequence can increase affinity.
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