Examples of 'framework sequence' in a sentence
Meaning of "framework sequence"
framework sequence - Refers to the specific order or structure in which tasks, events, or components are organized within a framework or system
How to use "framework sequence" in a sentence
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framework sequence
Introduction of a point mutation into the framework sequence.
These stable and soluble framework sequence exhibited high homology with the RabMabs.
The human framework pool is selected to provide maximum framework sequence diversity.
Such antibodies may have a framework sequence with high homology to the human framework sequences.
Fully human frameworks are those that are identical to a known human germline framework sequence.
In some instances the heavy chain framework sequence is the germline sequence.
A framework sequence from any human antibody may serve as the template for CDR grafting.
The acceptor framework can be a mature human antibody framework sequence or a consensus sequence.
Preferably, the human framework sequence will not itself be significantly immunogenic.
The LCVR will further comprise framework sequence.
A human framework sequence such as described above is best able to accept the murine-derived CDRs.
The HCVR will further comprise framework sequence.
In a still further aspect, the heavy chain framework sequence is a VH subgroup III consensus framework.
The antibody of claim 1 comprising human k subgroup llight chain consensus framework sequence.
In certain embodiments, at least a portion of the framework sequence is a human consensus framework sequence.
See also
The antibody of the invention may comprise human k subgroup 1light chain consensus framework sequence.
In one embodiment, the human framework sequence comprises a back-mutation.
In addition to CDR sequences, the LCVR and HCVR further comprise framework sequence.
In one aspect, the human framework sequence comprises a back-mutation.
The use according to claims 8-11, wherein the conserved framework sequence has gaps.
The analysis of the rest of the framework sequence shows 59 out of 87 residues are conserved.
Characterized in that the VI domain has the framework sequence of Seq.
The antibody of the disclosure may comprise a framework sequence which comprises a substitution at position 71, 73 and / or 78.
Determining which germline gene family the first framework sequence was derived from ;.
For example, in one embodiment, a variant kI consensus framework sequence may comprise a substitution at position 4.
Accordingly, the selection of an appropriate human VI acceptor framework sequence may further comprise,.
In a still further aspect, at least one of the framework sequence is the following,.
A HAM according to claim 2 wherein the framework sequence is LAY.
The use according to claim 8, wherein the conserved framework sequence is 2-5 residues.
Id . No. 4 and the VH domain has the framework sequence of Seq.
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