Examples of 'guide rnas' in a sentence
Meaning of "guide rnas"
guide rnas - This refers to molecules known as ribonucleic acids (RNAs) that provide instructions for the synthesis of proteins within a cell. RNAs play a crucial role in gene expression and protein production
How to use "guide rnas" in a sentence
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guide rnas
Guide RNAs can be provided in any form.
The pair comprises two guide RNAs.
The two guide RNAs need to be spaced as follows.
The design tool will identify single guide RNAs.
Guide RNAs are indicated in blue.
Methods and compositions for targeted genetic modification using paired guide RNAs.
Guide RNAs can also be a synthetically produced molecule prepared by chemical synthesis.
Table 4 presents the sequences of the guide RNAs.
Thus, truncated guide RNAs show reduced cleavage activity and specificity.
According to one aspect, the two or more guide RNAs are tracrRNAs.
Three independent guide RNAs ( gRNAs ) all generated biallelic mutations among mutant lines.
According to one aspect, the two or more guide RNAs are crRNAs.
Putative guide RNAs can also be produced in extracts from Drosophila S2 cells Fig.
In certain embodiments, the methods and mutations are used with chemically modified guide RNAs.
According to one aspect, the two or more guide RNAs are tracrRNA-crRNA fusions.
See also
The appended examples also identify an enzyme, Dicer, that can produce the putative guide RNAs.
Such domains can interact with guide RNAs ( gRNAs, described in more detail below ).
RNA recognition and / or RNA binding domains interact with guide RNAs.
Cas9 guide RNAs were designed for targeting the human AAVS1 locus.
For Cas9, short orthologs may be packaged along with guide RNAs into a single AAV.
These guide RNAs target the same sequences encoded by CRISPR1 and CRISPR2.
Compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter.
Figure 15 shows a graph depicting the function of different optimized guide RNAs.
The Cas9 was programmed by short guide RNAs ( gRNAs ) to cleave any sequence complementary them.
Cas9 nuclease is directed to specific sites on the genome by guide RNAs ( gRNAs ).
Targeting results when employing the various guide RNAs is shown in Table 15.
A CRISPR-based gene drive carries an altered gene, the Cas9 enzyme, and several guide RNAs.
The targeting efficiency when employing the various guide RNAs is shown in FIG . 19.
Such components include, for example, Cas proteins, CRISPR RNAs, tracrRNAs, and guide RNAs.
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Antisense RNAs can be classified in different ways
The cluster genes are produced as polycistronic RNAs
All these RNAs are expressed by adult hepatocytes
