Examples of 'hcl in dioxane' in a sentence
Meaning of "hcl in dioxane"
hcl in dioxane: This phrase likely refers to a chemical compound or scientific context involving the interaction of hydrochloric acid (HCl) with dioxane, which is a common solvent. It could pertain to a chemical reaction, experiment, or research study
How to use "hcl in dioxane" in a sentence
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hcl in dioxane
A solution of HCl in dioxane was added.
The residue was dissolved in ether and 2 equivalents of 4 N HCl in dioxane were added.
Acid deprotection using HCl in dioxane can provide pyrrolidine intermediate iii.
The paste was dissolved in methanol and 1 eq of HCl in dioxane was added.
A portion in ether was treated with HCl in dioxane to precipitate the corresponding hydrochloride salt.
The product was redissolved in dichoromethane and treated with excess 4M HCl in dioxane.
Reaction mixture was neutralized with HCl in dioxane and purified by reverse phase HPLC.
The foam was diluted with ether and treated with 4N HCl in dioxane.
Deprotection using 4N HCl in dioxane gives the corresponding hydrochloride salt.
This material was dissolved in MeOH and 4M HCl in dioxane was added.
Acidification with 4 N HCl in dioxane gave the hydrochloride salt as an off-white solid.
The amino amide was then converted to its hydrochloride salt using 4N HCl in dioxane.
Removal of the N-t-Boc protecting group with HCl in dioxane provided the amino intermediate.
For example a BOC protecting group can be removed by treating compound 4b with 4N HCl in dioxane.
The intermediate oil was stirred in 4N HCl in dioxane overnight at room temperature.
See also
The Boc group was removed by treating the compound with 1.5 mmol of HCl in dioxane.
This product was suspended in 4 N HCl in dioxane and stirred for several hours.
The oil was taken up in Et2O and treated with 4 N HCl in dioxane.
Compound XXXII is deprotected with 4M HCl in dioxane exposing the free hydrazide group.
After cooling to RT, the base was neutralized with one equivalent of HCl in dioxane ( 4 M ).
A solution of 2M HCl in dioxane was added until the pH was approximately 2.
The solid is dissolved in ethanol, treated with 4N HCl in dioxane and concentrated in vacuo.
Then 10 mL of 4M HCl in dioxane was slowly added with vigorous stirring.
This compound was stirred with 4 M HCl in dioxane overnight.
An acid, such as 4N HCl in dioxane is added to the reaction mixture.
Preferred conditions are 4N HCl in dioxane.
Quenching with 20 mL of 4N HCl in dioxane was followed by extraction with water.
The solid was immediately dissolved in methanol ( 5 mL ) and 4 N HCl in dioxane was added.
The same volume of 4N HCl in dioxane was added to make a 2N solution of HCl.
The purified compound is treated in 5 ml 4 M HCl in dioxane at rt for 2 h.
A further portion of HCl in dioxane was added ( 10 mL ) and stirring continued for 2 days.
Deprotection of 1 was carried out by stirring in 1M HCl in dioxane for 1h at room temperature.
A solution of HCl in dioxane ( 4 M ) was added dropwise until the pH was less than 4.
The solution was then stirred and 1.2 equivalents of 4M HCl in dioxane was added dropwise.
The same volume of 4N HCl in dioxane was added to make a 2N solution.
In a first phase, compound 7 is deprotected using HCl in dioxane to give ( XXV-a ).
Finally, treatment with HCl in dioxane gives the p-HO-EDDP as a hydrochloride salt ( Figure 5 ).
The resulting reaction mixture was stirred for 1 hour and acidified with HCl in dioxane ( 3.6 mmol ).
Preferred conditions are 4 N HCl in dioxane at room temperature for 18 hrs.
The reaction is then treated with a 4 M solution of HCl in dioxane ( 2 mL ).
The residue was treated with 4M HCl in dioxane ( 10 mL ) under reflux for 2 hours and concentrated.
The purified product was taken up in 4M HCl in dioxane ( 2 ml ).
To this was added 4 N HCl in dioxane ( 5 mL ) and stirred at RT overnight.
Oily residue is dissolved in ethanol, and 0.2 ml 4N HCl in dioxane are added.
The solid was dissolved in 4M HCl in dioxane and the mixture was heated to 50°C.
The oil was dissolved in dioxane followed by the addition of 4N HCl in dioxane ( 10 ml ).
With stirring under nitrogen 4N HCl in dioxane ( 3 ml ) was added vía syringe.
A solution of the free base in 100 ml EtOAc was treated with 7N HCl in dioxane.
The residue was treated with 4.0 M HCl in dioxane and stirred overnight.
In one embodiment, the reaction in Step 3 includes treating compound ( 3 ) with 4N HCl in dioxane.
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Examples of using Dioxane
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Dioxane due to presence of solvents in the plume
The compound is derived from dioxane by dehydrogenation
The dioxane is evaporated under reduced pressure
