Examples of 'hdaci' in a sentence
Meaning of "hdaci"
HDACi (noun): Histone deacetylase inhibitor, a type of compound used in epigenetic research and potential cancer treatments
How to use "hdaci" in a sentence
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hdaci
There was no HDACi accumulation on repated dosing.
It was not until later that valproic acid was identified as a HDACi.
The classical HDACi bind to the zinc containing catalytic domain of the HDACs.
The plot shows a slight positive deviation in the ratio of HDACi to cyclodextrin.
Some HDACi developed for cancer therapy showed beneficial effects against these disorders.
There has also been extensive effort to develop HDACi for cancer therapy.
The HDACi may be used in combination with BSO.
The calculated saturated solubilities of the complexed HDACi were plotted against the concentration of cyclodextrin.
Experiments have shown that the amount of acetylated histones increases in the presence of HDACi.
The BSO and benzamide HDACi may be administered together.
Iron Nitroloactate is also envisaged in combination with an HDACi.
HDACi are chemical compounds that interfere with the function of HDAC enzymes.
Combinations with BSO are preferred and combinations with at least one HDACi are particularly preferred.
The HDACi may be a class I HDACi.
Figure 4 illustrates one embodiment of a HDACi pharmacophore.
See also
In recent years, HDACi are being actively studied as a mitigator or treatment for neurodegenerative diseases.
However, there may be a risk of precipitating the HDACi if the pH is adjusted.
However, many uses of HDACi in medicine were discovered without knowledge of the underlying mechanism.
In this study we demonstrated that pi3k/akt pathway is a target to hdaci in bl cells.
Figure 11 shows data demonstrating how HDACi improve embryo quality in older stages of donor pollen.
This explains the numerous undesirable side-effects observed in many of the trials involving HDACi.
In one embodiment, the HDACi is also an HDAC inhibitor.
Amount of HDACi The pharmaceutical formulation comprises a therapeutically-effective amount of HDACi.
Despite this, BSO was tested to determine whether it might potentiate the effects of HDACi.
The HDACi may be any of those defined above, and particularly from class I HDACi 's.
Figure 3 shows a schematic diagram of MEF2-HDAC luciferase reporter assay HDACi.
A HDACi as defined herein ; and.
The three dimensional ( 3D ) graph shows the 3D surface of synergism between each HDACi and BSO.
Moreover, hdaci enhanced the expression of mirnas related to pi3k/akt pathway and prolife.
