Examples of 'hdacs' in a sentence
Meaning of "hdacs"
HDACs refers to histone deacetylases, a group of enzymes that play a role in gene expression and are targeted in certain medical treatments
How to use "hdacs" in a sentence
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hdacs
It serves as a positive control for HDACs.
Eleven different HDACs have been cloned from vertebrate organisms.
These amino acid residues are acetylated by HATs and deacetylated by HDACs.
Disruption of HDACs has been linked to a wide variety of human cancers.
It is preferred that compounds are selected which specifically inhibit only a subset of HDACs.
Small molecule inhibitors of HDACs and HATs are being investigated as cancer therapy.
The classical HDACi bind to the zinc containing catalytic domain of the HDACs.
Mammalian HDACs can be divided into three classes according to sequence homology.
Gene expression might be influenced by the enzymes histone acetyltransferases HATs and histone deacetylases HDACs.
Several structurally related HDACs have been described and fall into two classes.
HDACs modify chromatin through the deactylation of histones.
Eleven structurally related HDACs have been described and fall into two classes.
HDACs are involved in the regulation of a number of cellular processes.
Eleven structurally related HDACs have been described and fall into three classes.
HDACs modify chromatin through the deacetylation of histones.
See also
These associations augment the activities of DNMT or HDACs.
HDACs are enzymes that are believed to play a role in cancer progression.
HDIs should not be considered to act solely as enzyme inhibitors of HDACs.
HDACs also play an important role in the homeostasis of eukaryotic pathogens.
Different HDAC inhibitors have shown different activities on different classes of HDACs.
An additional seven HDACs h ave been identified which use NAD as a cofactor.
VPA is an inhibitor of HDACs.
HDACs are proteins that play an important role in the control of epigenetic mechanisms.
It is highly potent against class I and II HDACs.
HDACs are then targets of interest in cancer treatment caused by those fusion proteins.
Briefly, HeLa cell nuclear extracts were used as a source of HDACs.
HDACs are classified into three main groups based on their homology to yeast proteins.
In the past few years, distinct classes of HDACs have been identified in mammalian cells.
Class II HDACs are further characterized as class IIa HDACs and class IIb HDACs.
There remains a need in the art for new, well-tolerated and more efficacious inhibitors of HDACs.
HDACs form multiprotein complexes with many regulatory proteins inside the cell.
Therefore the correct name for HDACs would be lysine-specific protein deacetylases.
HDACs are separated into three distinct classes based on their homology to yeast transcriptional repressors.
In this review, we focus on the biology of class II HDACs.
HDACs are categorized into two classes.
HATs facilitate acetylation, and HDACs remove the acetyl group.
Importantly, HDACs have been linked to cancer, as well as other health conditions.
S1P has been shown to directly inhibit the histone deacetylase activity of HDACs.
Class III HDACs are known as sirtuins.
It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs.
Eight human HDACs have been cloned so far,.
Similar tubulin deacetylation assay using the class II HDACs as described for ( B ).
Furthermore, hdacs have emerged as promising targets in the treatment of hematological malignancies.
According to specific examples, the HDAC inhibitor is a selective inhibitor of type II HDACs.
Inhibitors of HDACs modulate transcription and induce cell growth arrest, differentiation, and apoptosis.
Yeast Sir2 is the founding member of Class III HDACs.
Conversely, HDACs serve to remove acetyl groups from histones and thereby repress transcription.
Figure 3 presents a proposed mechanism of action of zinc-dependent HDACs.
HDACs are a family of 11 enzymes that seem to act as master regulators of gene expression.
Over-expression of HDACs repress muscle-specific promoters.
